Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085280752> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2085280752 endingPage "S207" @default.
- W2085280752 startingPage "S207" @default.
- W2085280752 abstract "Neuronal activation leads to an increase in regional cerebral blood flow (rCBF) and blood oxygenation (rCBO). The underlying mechanisms of neurovascular coupling are poorly understood. Recently a new model of activity induced vascular regulation was proposed by Stamler et al. (1997) based on the fact that nitric oxide (NO), a potent vasodilator, binds to hemoglobin in the oxygenated state (oxy-Hb) but is released upon deoxygenation of hemoglobin (deoxy-Hb). It was suggested that during cellular activity oxygen consumption locally increases which causes deoxygenation of hemoglobin and release of NO. Indeed it has recently been shown that red blood cell-bound NO mediates hypoxic vasodilation in vitro, and transpulmonary gradients of hemoglobin-bound NO are evident in patients with congestive heart failure (Datta et al., 2004). According to this elegant model of combined oxygen and NO release, blood flow will be directly matched to tissue oxygen demands. To test this model as a physiological mechanism of neurovascular coupling in the brain, we measured rCBF and rCBO responses to functional activation under hyperbaric oxygenation (3 ATA, FiO2 1.0) in the anesthetized rat. During hyperbaric oxygenation oxygen supply to tissue is entirely provided through physically dissolved oxygen. During activation no deoxygenation of hemoglobin and thus no allosteric release of NO occurs. Laser Doppler flowmetry combined with microfiber Hb-spectroscopy was performed through the thinned skull in rats to measure relative changes in rCBF and rCBO and cortical hemoglobin saturation. Averaged rCBF and rCBO responses to electrical forepaw stimulation (3 Hz, 10 s stimulation period) were recorded under normobaric normoxia and compared with responses during hyperbaric hyperoxygenation. Hyperbaric hyperoxygenation increased hemoglobin saturation within the microcirculation from 44 2 to 103 3%. The deoxy-Hb decrease normally occurring during functional activation disappeared. The oxy-Hb increase was unchanged, and the rCBF response to functional activation was increased but not decreased under hyperbaric hyperoxygenation compared with control responses. In most animals the observed increase in the rCBF response was paralleled by an increase in the amplitude of somatosensory evoked potentials. Our results suggest that in contrast to the in-vitro situation and to pathophysiological conditions of severe hypoxia rCBF regulation during physiological neuronal activation involves other mechanisms than oxygen-dependent delivery and release of NO from hemoglobin." @default.
- W2085280752 created "2016-06-24" @default.
- W2085280752 creator A5033798967 @default.
- W2085280752 creator A5046050028 @default.
- W2085280752 creator A5049579744 @default.
- W2085280752 creator A5049828692 @default.
- W2085280752 creator A5050240866 @default.
- W2085280752 creator A5054340252 @default.
- W2085280752 creator A5058972647 @default.
- W2085280752 creator A5075931942 @default.
- W2085280752 creator A5085598681 @default.
- W2085280752 date "2005-08-01" @default.
- W2085280752 modified "2023-10-03" @default.
- W2085280752 title "Allosteric release of nitric oxide from hemoglobin does not mediate neurovascular coupling" @default.
- W2085280752 doi "https://doi.org/10.1038/sj.jcbfm.9591524.0207" @default.
- W2085280752 hasPublicationYear "2005" @default.
- W2085280752 type Work @default.
- W2085280752 sameAs 2085280752 @default.
- W2085280752 citedByCount "2" @default.
- W2085280752 crossrefType "journal-article" @default.
- W2085280752 hasAuthorship W2085280752A5033798967 @default.
- W2085280752 hasAuthorship W2085280752A5046050028 @default.
- W2085280752 hasAuthorship W2085280752A5049579744 @default.
- W2085280752 hasAuthorship W2085280752A5049828692 @default.
- W2085280752 hasAuthorship W2085280752A5050240866 @default.
- W2085280752 hasAuthorship W2085280752A5054340252 @default.
- W2085280752 hasAuthorship W2085280752A5058972647 @default.
- W2085280752 hasAuthorship W2085280752A5075931942 @default.
- W2085280752 hasAuthorship W2085280752A5085598681 @default.
- W2085280752 hasConcept C105572291 @default.
- W2085280752 hasConcept C105702510 @default.
- W2085280752 hasConcept C12554922 @default.
- W2085280752 hasConcept C126322002 @default.
- W2085280752 hasConcept C131584629 @default.
- W2085280752 hasConcept C15744967 @default.
- W2085280752 hasConcept C166342909 @default.
- W2085280752 hasConcept C169760540 @default.
- W2085280752 hasConcept C170493617 @default.
- W2085280752 hasConcept C185592680 @default.
- W2085280752 hasConcept C191897082 @default.
- W2085280752 hasConcept C192562407 @default.
- W2085280752 hasConcept C2778917026 @default.
- W2085280752 hasConcept C42219234 @default.
- W2085280752 hasConcept C519581460 @default.
- W2085280752 hasConcept C55493867 @default.
- W2085280752 hasConcept C71924100 @default.
- W2085280752 hasConcept C86803240 @default.
- W2085280752 hasConceptScore W2085280752C105572291 @default.
- W2085280752 hasConceptScore W2085280752C105702510 @default.
- W2085280752 hasConceptScore W2085280752C12554922 @default.
- W2085280752 hasConceptScore W2085280752C126322002 @default.
- W2085280752 hasConceptScore W2085280752C131584629 @default.
- W2085280752 hasConceptScore W2085280752C15744967 @default.
- W2085280752 hasConceptScore W2085280752C166342909 @default.
- W2085280752 hasConceptScore W2085280752C169760540 @default.
- W2085280752 hasConceptScore W2085280752C170493617 @default.
- W2085280752 hasConceptScore W2085280752C185592680 @default.
- W2085280752 hasConceptScore W2085280752C191897082 @default.
- W2085280752 hasConceptScore W2085280752C192562407 @default.
- W2085280752 hasConceptScore W2085280752C2778917026 @default.
- W2085280752 hasConceptScore W2085280752C42219234 @default.
- W2085280752 hasConceptScore W2085280752C519581460 @default.
- W2085280752 hasConceptScore W2085280752C55493867 @default.
- W2085280752 hasConceptScore W2085280752C71924100 @default.
- W2085280752 hasConceptScore W2085280752C86803240 @default.
- W2085280752 hasIssue "1_suppl" @default.
- W2085280752 hasLocation W20852807521 @default.
- W2085280752 hasOpenAccess W2085280752 @default.
- W2085280752 hasPrimaryLocation W20852807521 @default.
- W2085280752 hasRelatedWork W1974990903 @default.
- W2085280752 hasRelatedWork W1998588297 @default.
- W2085280752 hasRelatedWork W2040992536 @default.
- W2085280752 hasRelatedWork W2049701915 @default.
- W2085280752 hasRelatedWork W2065923892 @default.
- W2085280752 hasRelatedWork W2085030105 @default.
- W2085280752 hasRelatedWork W2415752239 @default.
- W2085280752 hasRelatedWork W2748952813 @default.
- W2085280752 hasRelatedWork W2899084033 @default.
- W2085280752 hasRelatedWork W3194520185 @default.
- W2085280752 hasVolume "25" @default.
- W2085280752 isParatext "false" @default.
- W2085280752 isRetracted "false" @default.
- W2085280752 magId "2085280752" @default.
- W2085280752 workType "article" @default.