Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085282685> ?p ?o ?g. }
- W2085282685 endingPage "72" @default.
- W2085282685 startingPage "65" @default.
- W2085282685 abstract "Calcium deficiency causes osteoporosis in experimental animals because the skeleton is sacrificed for the preservation of the plasma (ionic) calcium and to meet obligatory calcium losses in the feces and urine. (Vitamin D deficiency, on the other hand, causes rickets and osteomalacia largely because of the loss of the calcemic action of vitamin D, which leads to hypocalcemia, secondary hyperparathyroidism, and hypophosphatemia.) The concept that human osteoporosis, particularly in postmenopausal women, results from negative calcium balance represents a working hypothesis that fits many, but not all of the available data. In normal women, the crucial event is a rise in obligatory urinary calcium loss, which may result from an increase in the complexed fraction of the plasma calcium, due in turn to an increase in plasma bicarbonate. Prospective trials with calcium supplements have, however, yielded conflicting results. In osteoporotic women, a further increase in urinary calcium combined with calcium malabsorption produces a further increase in bone resorption, but some impairment of bone formation due to declining androgens may constitute an additional risk factor with advancing age. The suppressibility of urinary hydroxyproline by calcium supplementation in those patients who can absorb calcium, and by calcitriol in those who cannot, supports the calcium deficiency model, but more trials are needed to establish its validity." @default.
- W2085282685 created "2016-06-24" @default.
- W2085282685 creator A5001970849 @default.
- W2085282685 creator A5041210425 @default.
- W2085282685 date "2009-04-27" @default.
- W2085282685 modified "2023-09-27" @default.
- W2085282685 title "The Calcium Deficiency Model for Osteoporosis" @default.
- W2085282685 cites W168458530 @default.
- W2085282685 cites W1907394035 @default.
- W2085282685 cites W1945658545 @default.
- W2085282685 cites W1960094237 @default.
- W2085282685 cites W1974534962 @default.
- W2085282685 cites W1988213418 @default.
- W2085282685 cites W2011050066 @default.
- W2085282685 cites W2019205281 @default.
- W2085282685 cites W2029206794 @default.
- W2085282685 cites W2038046038 @default.
- W2085282685 cites W2047366838 @default.
- W2085282685 cites W2054591020 @default.
- W2085282685 cites W2062729355 @default.
- W2085282685 cites W2066962971 @default.
- W2085282685 cites W2078629144 @default.
- W2085282685 cites W2092525005 @default.
- W2085282685 cites W2092791248 @default.
- W2085282685 cites W2100003961 @default.
- W2085282685 cites W2108459154 @default.
- W2085282685 cites W2153927941 @default.
- W2085282685 cites W2161295457 @default.
- W2085282685 cites W2168634441 @default.
- W2085282685 cites W2173052686 @default.
- W2085282685 cites W2268623727 @default.
- W2085282685 cites W2327465611 @default.
- W2085282685 cites W2465569835 @default.
- W2085282685 cites W2524061995 @default.
- W2085282685 doi "https://doi.org/10.1111/j.1753-4887.1989.tb02794.x" @default.
- W2085282685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2649803" @default.
- W2085282685 hasPublicationYear "2009" @default.
- W2085282685 type Work @default.
- W2085282685 sameAs 2085282685 @default.
- W2085282685 citedByCount "72" @default.
- W2085282685 countsByYear W20852826852012 @default.
- W2085282685 countsByYear W20852826852014 @default.
- W2085282685 countsByYear W20852826852016 @default.
- W2085282685 countsByYear W20852826852017 @default.
- W2085282685 countsByYear W20852826852021 @default.
- W2085282685 countsByYear W20852826852022 @default.
- W2085282685 countsByYear W20852826852023 @default.
- W2085282685 crossrefType "journal-article" @default.
- W2085282685 hasAuthorship W2085282685A5001970849 @default.
- W2085282685 hasAuthorship W2085282685A5041210425 @default.
- W2085282685 hasConcept C124490489 @default.
- W2085282685 hasConcept C126322002 @default.
- W2085282685 hasConcept C134018914 @default.
- W2085282685 hasConcept C2776079296 @default.
- W2085282685 hasConcept C2776541429 @default.
- W2085282685 hasConcept C2776697488 @default.
- W2085282685 hasConcept C2778049618 @default.
- W2085282685 hasConcept C2778573388 @default.
- W2085282685 hasConcept C2778838027 @default.
- W2085282685 hasConcept C2780439177 @default.
- W2085282685 hasConcept C2781208988 @default.
- W2085282685 hasConcept C519063684 @default.
- W2085282685 hasConcept C673006 @default.
- W2085282685 hasConcept C71924100 @default.
- W2085282685 hasConcept C87975464 @default.
- W2085282685 hasConceptScore W2085282685C124490489 @default.
- W2085282685 hasConceptScore W2085282685C126322002 @default.
- W2085282685 hasConceptScore W2085282685C134018914 @default.
- W2085282685 hasConceptScore W2085282685C2776079296 @default.
- W2085282685 hasConceptScore W2085282685C2776541429 @default.
- W2085282685 hasConceptScore W2085282685C2776697488 @default.
- W2085282685 hasConceptScore W2085282685C2778049618 @default.
- W2085282685 hasConceptScore W2085282685C2778573388 @default.
- W2085282685 hasConceptScore W2085282685C2778838027 @default.
- W2085282685 hasConceptScore W2085282685C2780439177 @default.
- W2085282685 hasConceptScore W2085282685C2781208988 @default.
- W2085282685 hasConceptScore W2085282685C519063684 @default.
- W2085282685 hasConceptScore W2085282685C673006 @default.
- W2085282685 hasConceptScore W2085282685C71924100 @default.
- W2085282685 hasConceptScore W2085282685C87975464 @default.
- W2085282685 hasIssue "3" @default.
- W2085282685 hasLocation W20852826851 @default.
- W2085282685 hasLocation W20852826852 @default.
- W2085282685 hasOpenAccess W2085282685 @default.
- W2085282685 hasPrimaryLocation W20852826851 @default.
- W2085282685 hasRelatedWork W1997142557 @default.
- W2085282685 hasRelatedWork W2016926706 @default.
- W2085282685 hasRelatedWork W2058703046 @default.
- W2085282685 hasRelatedWork W2064236298 @default.
- W2085282685 hasRelatedWork W2085282685 @default.
- W2085282685 hasRelatedWork W2167008166 @default.
- W2085282685 hasRelatedWork W2407252051 @default.
- W2085282685 hasRelatedWork W2417392509 @default.
- W2085282685 hasRelatedWork W2418517950 @default.
- W2085282685 hasRelatedWork W4253300128 @default.
- W2085282685 hasVolume "47" @default.
- W2085282685 isParatext "false" @default.
- W2085282685 isRetracted "false" @default.