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- W2085283746 abstract "Patients with primary pulmonary hypertension develop hemodynamic changes characterized by an elevation in pulmonary artery pressure and pulmonary vascular resistance, and by a reduced cardiac output.’ There does not appear to be any relationship, however, between the magnitude of these changes and the duration of the illness.2 Consequently it becomes difficult to distinguish patients early in the course of their disease from those who have had the illness for many years. It has been suggested that the acute response to vasodilator drugs may be helpful in this regard.3 Upon making the diagnosis of primary pulmonary hypertension it is recommended practice to test the responsiveness of the pulmonary vasculature with vasodilator drugs given intravenously at the time of cardiac catheterization4 A substantial reduction in the pulmonary vascular resistance following drug administration has been interpreted as resulting from vasodilation within the pulmonary vascular bed,5*6 suggesting that patients who respond favorably are earlier in the course of their illness, still having reversible vasoconstriction.3 Recent successes in the use of vasodilator drugs for the treatment of essential hypertension have stimulated interest in the use of these drugs for patients with primary pulmonary hypertension as well. Demonstration of a fall in the pulmonary" @default.
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- W2085283746 date "1983-01-01" @default.
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- W2085283746 title "Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: Guidelines for determining a pulmonary vasodilator response" @default.
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- W2085283746 doi "https://doi.org/10.1016/0002-8703(83)90288-0" @default.
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