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- W2085286876 abstract "Macrophages recovered from regressing Moloney sarcomas lose their capacity to kill tumor cells when held 12–24 h in culture. Exposure of this population to low concentrations (ng/ml range) of bacterial lipopolysaccharide will cause a rapid resurgence of cytolytic activity, however. By using electron spin resonance techniques and either 5- or 12-doxyl stearate spin labels, we have shown that exposure of cultured tumor macrophages to lipopolysaccharide (100 ng/ml) is followed by plasma membrane perturbation. The change was most pronounced 3–4 h after stimulation, and had subsided within 5–6 h. The relationship of the described perturbation to the induction of killing cannot be determined from these studies; however, neither cytolytic activity nor the membrane change developed in other kinds of macrophages exposed to similar concentrations of lipopolysaccharide." @default.
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- W2085286876 date "1979-03-01" @default.
- W2085286876 modified "2023-09-24" @default.
- W2085286876 title "Membrane perturbation of macrophages stimulated by bacterial lipopolysaccharide" @default.
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- W2085286876 doi "https://doi.org/10.1016/0006-291x(79)91828-x" @default.
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