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• W2085287703 abstract "Gadolinium (Gd3+) is a trivalent ion of the lanthanide series which has a high charge density and a similar ionic radius to Ca2+. The effects of gadolinium ions on [3H]noradrenaline output and 45Ca fluxes during resting conditions and stimulation were investigated in cultured bovine chromaffin cells. Chromaffin cells isolated from bovine adrenal medullae were plated on collagen-coated dishes (106 cells/dish) in a medium containing 10% fetal calf serum. Seven-day-old cells were used in all studies. Exposure of chromaffin cells to 0.05mM Gd3+ produced 80 ± 5% and 81 ± 4% inhibition of the secretory responses to 10−4M acetylcholine and 56 mM K+ respectively. Doubling of the extracellular concentration of Gd3+ produced an 87 ± 3% and 100 ± 2% inhibition of the acetylcholine-induced and K+-induced release of [ 3H]noradrenaline. Gd3+ (0.05 mM) also produced a parallel shift to the right in the dose-response relationship between extracellular Ca2+ concentrations and [ 3H]noradrenaline output during acetylcholine stimulation. This observation suggests a competitive antagonism between Ca2+ and Gd3+ in stimulus-secretion coupling. Gd3+ (0.05 mM) was an effective inhibitor (92.3 ± 0.7%) of the uptake of 45Ca into chromaffin cells induced by a depolarizing concentration (56 mM) of K+. Furthermore, Gd3+ also inhibited the increase in both Ca2+ − Ca2+ exchange mechanism and [ 3H]noradrenaline output observed in chromaffin cells upon the reintroduction of Ca2+ into a Ca2+]-free incubation medium. The results, which were obtained using low concentrations of Gd3+, indicate that gadolinium is a powerful inhibitor of the Ca2+ movements which are required for triggering amine release from chromaffin cells by different secretagogues. Moreover, the results also suggest that Gd3+ might be a useful tool for release and electrophysiological studies in other Ca2+-dependent systems." @default.
• W2085287703 created "2016-06-24" @default.
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• W2085287703 date "1982-07-01" @default.
• W2085287703 modified "2023-09-27" @default.
• W2085287703 title "The gadolinium ion: A potent blocker of calcium channels and catecholamine release from cultured chromaffin cells" @default.
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• W2085287703 doi "https://doi.org/10.1016/0306-4522(82)90019-7" @default.
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