Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085288423> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2085288423 endingPage "70" @default.
- W2085288423 startingPage "61" @default.
- W2085288423 abstract "We investigated how the DNA status correlates with the aging process in organisms, in different organs and in tissues using two inbred strains of mice, which are genetically related but have different senescence patterns. The SAMP1 mice belong to an accelerated senescence-prone and short lived strain, the other, SAMR1 mice are from an accelerated senescence-resistant and long lived strain. Using the alkaline filter elution technique, pieces of tissues from six organs: lung, intestine, liver, brain, muscle, and heart have been examined for DNA damage, mainly DNA single strand breaks. It was shown that in newborns the DNA damage is minimal, and it was increased significantly with calendric age in all organs in both strains. Although the correlation of DNA damage with aging differed in the different six organs, damage was significantly higher in SAMP1 mice than SAMR1 mice at later life in all organs. This is another remarkable example for the strong correlation of DNA damage and aging process, especially with senescence acceleration." @default.
- W2085288423 created "2016-06-24" @default.
- W2085288423 creator A5027168306 @default.
- W2085288423 creator A5036810313 @default.
- W2085288423 creator A5073321511 @default.
- W2085288423 creator A5074165116 @default.
- W2085288423 creator A5090842937 @default.
- W2085288423 date "2000-09-01" @default.
- W2085288423 modified "2023-10-01" @default.
- W2085288423 title "Age-associated DNA damage is accelerated in the senescence-accelerated mice" @default.
- W2085288423 cites W1506053156 @default.
- W2085288423 cites W1978038389 @default.
- W2085288423 cites W1986537087 @default.
- W2085288423 cites W1987896111 @default.
- W2085288423 cites W1994598785 @default.
- W2085288423 cites W1997538790 @default.
- W2085288423 cites W2013865976 @default.
- W2085288423 cites W2021723492 @default.
- W2085288423 cites W2031400881 @default.
- W2085288423 cites W2044176662 @default.
- W2085288423 cites W2053296157 @default.
- W2085288423 cites W2056206142 @default.
- W2085288423 cites W2057512249 @default.
- W2085288423 cites W2086114339 @default.
- W2085288423 cites W2088038548 @default.
- W2085288423 cites W2088897584 @default.
- W2085288423 cites W2093153677 @default.
- W2085288423 cites W2150932434 @default.
- W2085288423 doi "https://doi.org/10.1016/s0047-6374(00)00158-5" @default.
- W2085288423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10989125" @default.
- W2085288423 hasPublicationYear "2000" @default.
- W2085288423 type Work @default.
- W2085288423 sameAs 2085288423 @default.
- W2085288423 citedByCount "33" @default.
- W2085288423 countsByYear W20852884232012 @default.
- W2085288423 countsByYear W20852884232013 @default.
- W2085288423 crossrefType "journal-article" @default.
- W2085288423 hasAuthorship W2085288423A5027168306 @default.
- W2085288423 hasAuthorship W2085288423A5036810313 @default.
- W2085288423 hasAuthorship W2085288423A5073321511 @default.
- W2085288423 hasAuthorship W2085288423A5074165116 @default.
- W2085288423 hasAuthorship W2085288423A5090842937 @default.
- W2085288423 hasConcept C105702510 @default.
- W2085288423 hasConcept C118820876 @default.
- W2085288423 hasConcept C143425029 @default.
- W2085288423 hasConcept C147789679 @default.
- W2085288423 hasConcept C185592680 @default.
- W2085288423 hasConcept C2778022156 @default.
- W2085288423 hasConcept C522857546 @default.
- W2085288423 hasConcept C54355233 @default.
- W2085288423 hasConcept C552990157 @default.
- W2085288423 hasConcept C86803240 @default.
- W2085288423 hasConceptScore W2085288423C105702510 @default.
- W2085288423 hasConceptScore W2085288423C118820876 @default.
- W2085288423 hasConceptScore W2085288423C143425029 @default.
- W2085288423 hasConceptScore W2085288423C147789679 @default.
- W2085288423 hasConceptScore W2085288423C185592680 @default.
- W2085288423 hasConceptScore W2085288423C2778022156 @default.
- W2085288423 hasConceptScore W2085288423C522857546 @default.
- W2085288423 hasConceptScore W2085288423C54355233 @default.
- W2085288423 hasConceptScore W2085288423C552990157 @default.
- W2085288423 hasConceptScore W2085288423C86803240 @default.
- W2085288423 hasIssue "1-2" @default.
- W2085288423 hasLocation W20852884231 @default.
- W2085288423 hasLocation W20852884232 @default.
- W2085288423 hasOpenAccess W2085288423 @default.
- W2085288423 hasPrimaryLocation W20852884231 @default.
- W2085288423 hasRelatedWork W1828691184 @default.
- W2085288423 hasRelatedWork W2002128513 @default.
- W2085288423 hasRelatedWork W2019276374 @default.
- W2085288423 hasRelatedWork W2058108472 @default.
- W2085288423 hasRelatedWork W2085288423 @default.
- W2085288423 hasRelatedWork W2093322115 @default.
- W2085288423 hasRelatedWork W2402678912 @default.
- W2085288423 hasRelatedWork W2797023968 @default.
- W2085288423 hasRelatedWork W4313295416 @default.
- W2085288423 hasRelatedWork W2092874662 @default.
- W2085288423 hasVolume "118" @default.
- W2085288423 isParatext "false" @default.
- W2085288423 isRetracted "false" @default.
- W2085288423 magId "2085288423" @default.
- W2085288423 workType "article" @default.