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• W2085288538 abstract "The thioredoxin/peroxiredoxin system comprises a redox-regulated antioxidant family in human lung; its significance, regulation, or oxidation has not been evaluated in smoking-related lung diseases. Here, we present the expression of the thioredoxin/peroxiredoxin system in lung biopsies from normal lung (n = 14), smokers (n = 21), and patients with chronic obstructive pulmonary disease (COPD, n = 38), and assess the possible inactivation/oxidation of this system by nonreducing Western blotting, two-dimensional gel electrophoresis, and mass spectrometry. Our study shows that the thiol status of the Trx/Prx-system can be modulated in vitro, but it appears to have high resistance against the oxidative stress in COPD." @default.
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• W2085288538 date "2008-04-01" @default.
• W2085288538 modified "2023-09-23" @default.
• W2085288538 title "Does the Oxidative Stress in Chronic Obstructive Pulmonary Disease Cause Thioredoxin/Peroxiredoxin Oxidation?" @default.
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• W2085288538 doi "https://doi.org/10.1089/ars.2007.1952" @default.
• W2085288538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18179358" @default.
• W2085288538 hasPublicationYear "2008" @default.
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