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• W2085291246 abstract "1 Plasma protein extravasation (PPE) responses in guinea-pig skin have been measured using accumulation of intravenously injected 125I-labelled human serum albumin (125I-HSA). 2 The nitric oxide (NO) synthase inhibitor, NG-nitro-l-arginine methyl ester (l-NAME; 0.1 μmol/site) significantly reduced responses to bradykinin (BK; 0.5 nmol/site) or histamine (4.5 nmol/site) when co-injected with the inflammatory mediators. d-NAME (0.1 μmol/site) had no significant effect. 3 l-NAME (0.01–0.1 μmol/site) appeared to produce greater shifts of the dose-response curve to BK (0.1–3 nmol/site) than of that to histamine (2.3–27 nmol/site). Both 0.01 and 0.1 μmol l-NAME/site significantly reduced the response to BK (0.5 nmol/site) whereas only the higher dose of l-NAME produced a significant reduction in the response to histamine (4.5 nmol/site). 4 The inhibitory effect of l-NAME (0.1 μmol/site) on the response to BK but not on that to histamine was significantly reversed by l-arginine (l-Arg; 10 μmol/site). d-arginine (d-Arg; 10 μmol/site) had no significant effect in either case. 5 l-Arg (10 μmol/site) significantly enhanced the response to BK but inhibited that to histamine. d-Arg (10 μmol/site) had no significant effect on BK but significantly inhibited histamine. l-Lysine (l-Lys: 10 μmol/site) had no significant effect on the response to either BK or histamine. 6 l-Arg (100 mM) had a significant inhibitory effect on isometric contractions to histamine, but not BK in guinea-pig ileum in vitro. d-Arg (100 mM) also significantly inhibited histamine responses whereas l-Lys (100 mM) had no effect. 7 The α-adrenoceptor agonist, phenylephrine (0.3 or 6 nmol/site) inhibited matched responses to BK (0.5 nmol/site) or histamine (5.4 nmol/site) to comparable degrees, but gave significant inhibition only at the higher dose. 8 The β-adrenoceptor agonist, isoprenaline (0.5 or 10 nmol/site) had a significant inhibitory effect on the response to histamine (5.4 nmol/site) whereas a comparable response to BK (0.5 nmol/site) was significantly reduced by the higher dose only. 9 Our results with l-NAME suggest that local production of NO is involved in the modulation of mediator-induced vascular permeability. It is possible that NO may play a greater role in the extravasation response to BK than to that induced by histamine. 10 The differential effects of l-NAME and isoprenaline on BK- and histamine-induced PPE raise the possibility that BK and histamine may induce vascular permeability via different mechanisms in guinea-pig skin." @default.
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• W2085291246 date "1994-01-01" @default.
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• W2085291246 title "Cutaneous permeability responses to bradykinin and histamine in the guinea-pig: possible differences in their mechanism of action" @default.
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• W2085291246 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14038.x" @default.
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