Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085293089> ?p ?o ?g. }
- W2085293089 endingPage "197" @default.
- W2085293089 startingPage "189" @default.
- W2085293089 abstract "An episode of status epilepticus (SE), if left untreated, can lead to death, or brain damage with long-term neurological consequences, including the development of epilepsy. The most common first-line treatment of SE is administration of benzodiazepines (BZs). However, the efficacy of BZs in terminating seizures is reduced with time after the onset of SE; this is accompanied by a reduced efficacy in protecting the hippocampus against neuronal damage, and is associated with impaired function and internalization of hippocampal GABAA receptors. In the present study, using Fluoro-Jade C staining, we found that administration of diazepam to rats at 3 h after the onset of kainic acid-induced SE, at a dose sufficient to terminate SE, had no protective effect on the hippocampus, but produced a significant reduction in neuronal degeneration in the amygdala, piriform cortex, and endopiriform nucleus, examined on days 7–9 after SE. Thus, in contrast to the hippocampus, the amygdala and other limbic structures are responsive to neuroprotection by BZs after prolonged SE, suggesting that GABAA receptors are not significantly altered in these structures during SE." @default.
- W2085293089 created "2016-06-24" @default.
- W2085293089 creator A5006836985 @default.
- W2085293089 creator A5007014193 @default.
- W2085293089 creator A5010073717 @default.
- W2085293089 creator A5054323061 @default.
- W2085293089 creator A5088339087 @default.
- W2085293089 date "2009-01-07" @default.
- W2085293089 modified "2023-09-26" @default.
- W2085293089 title "Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis" @default.
- W2085293089 cites W110932280 @default.
- W2085293089 cites W1537245126 @default.
- W2085293089 cites W1541490300 @default.
- W2085293089 cites W1554190798 @default.
- W2085293089 cites W1565479331 @default.
- W2085293089 cites W1983021935 @default.
- W2085293089 cites W1992916966 @default.
- W2085293089 cites W1994308963 @default.
- W2085293089 cites W1995460856 @default.
- W2085293089 cites W1996502255 @default.
- W2085293089 cites W1996529782 @default.
- W2085293089 cites W1999151021 @default.
- W2085293089 cites W2009093172 @default.
- W2085293089 cites W2017192155 @default.
- W2085293089 cites W2022378061 @default.
- W2085293089 cites W2023823540 @default.
- W2085293089 cites W2031849673 @default.
- W2085293089 cites W2034323512 @default.
- W2085293089 cites W2035862839 @default.
- W2085293089 cites W2036467957 @default.
- W2085293089 cites W2039738625 @default.
- W2085293089 cites W2047978949 @default.
- W2085293089 cites W2048559115 @default.
- W2085293089 cites W2051099974 @default.
- W2085293089 cites W2057230367 @default.
- W2085293089 cites W2061810763 @default.
- W2085293089 cites W2063413260 @default.
- W2085293089 cites W2065299306 @default.
- W2085293089 cites W2066594153 @default.
- W2085293089 cites W2069507189 @default.
- W2085293089 cites W2072043599 @default.
- W2085293089 cites W2076302671 @default.
- W2085293089 cites W2076862449 @default.
- W2085293089 cites W2080878352 @default.
- W2085293089 cites W2081992705 @default.
- W2085293089 cites W2083310100 @default.
- W2085293089 cites W2084303371 @default.
- W2085293089 cites W2087018586 @default.
- W2085293089 cites W2088178662 @default.
- W2085293089 cites W2092700031 @default.
- W2085293089 cites W2095909863 @default.
- W2085293089 cites W2096717380 @default.
- W2085293089 cites W2097386446 @default.
- W2085293089 cites W2103140876 @default.
- W2085293089 cites W2103946141 @default.
- W2085293089 cites W2106001183 @default.
- W2085293089 cites W2106579385 @default.
- W2085293089 cites W2138152051 @default.
- W2085293089 cites W2147146794 @default.
- W2085293089 cites W2159826847 @default.
- W2085293089 cites W2166447911 @default.
- W2085293089 cites W2176076159 @default.
- W2085293089 cites W2443618585 @default.
- W2085293089 doi "https://doi.org/10.1007/s00726-008-0227-2" @default.
- W2085293089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2811765" @default.
- W2085293089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19127342" @default.
- W2085293089 hasPublicationYear "2009" @default.
- W2085293089 type Work @default.
- W2085293089 sameAs 2085293089 @default.
- W2085293089 citedByCount "33" @default.
- W2085293089 countsByYear W20852930892012 @default.
- W2085293089 countsByYear W20852930892013 @default.
- W2085293089 countsByYear W20852930892014 @default.
- W2085293089 countsByYear W20852930892015 @default.
- W2085293089 countsByYear W20852930892017 @default.
- W2085293089 countsByYear W20852930892018 @default.
- W2085293089 countsByYear W20852930892020 @default.
- W2085293089 countsByYear W20852930892021 @default.
- W2085293089 countsByYear W20852930892022 @default.
- W2085293089 countsByYear W20852930892023 @default.
- W2085293089 crossrefType "journal-article" @default.
- W2085293089 hasAuthorship W2085293089A5006836985 @default.
- W2085293089 hasAuthorship W2085293089A5007014193 @default.
- W2085293089 hasAuthorship W2085293089A5010073717 @default.
- W2085293089 hasAuthorship W2085293089A5054323061 @default.
- W2085293089 hasAuthorship W2085293089A5088339087 @default.
- W2085293089 hasBestOaLocation W20852930892 @default.
- W2085293089 hasConcept C126322002 @default.
- W2085293089 hasConcept C134018914 @default.
- W2085293089 hasConcept C148762608 @default.
- W2085293089 hasConcept C15744967 @default.
- W2085293089 hasConcept C169760540 @default.
- W2085293089 hasConcept C170493617 @default.
- W2085293089 hasConcept C25498285 @default.
- W2085293089 hasConcept C2776108384 @default.
- W2085293089 hasConcept C2776175493 @default.
- W2085293089 hasConcept C2776925932 @default.
- W2085293089 hasConcept C2777341932 @default.