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- W2085293319 abstract "We characterized differences in the structural organization of the MYCN amplicons of a number of neuroblastomas by analyzing 8 contigs spanning 330 kb cloned from the MYCN amplicon of a neuroblastoma cell line. Some regions were amplified in almost all specimens, the conserved regions (CRs), and others were differentially amplified in some subsets, the non-conserved regions (NCRs). CRs constituted only 20% of the 330 kb region, with the remainder being NCRs. The regions that inevitably co-segregate with the MYCN gene make up the core, whereas flanking regions are retained at random. If a histogram of the frequency with which the amplified NCR sequences from one specimen match those of the cell line MC-NB-1 shows a random distribution, the NCRs would co-segregate with MYCN as a result of random events. However, both the tumors and cell lines/xenografts showed a distribution with two distinct peaks; one from a group containing a small number of sequences with a fairly high degree of homology to the NCRs of MC-NB-1, and the other from a group containing a large number of sequences with little homology. These results indicate that the flanking segments are preferentially co-segregated with MYCN by a non-random mechanism. © 1993 Wiley-Liss, Inc." @default.
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- W2085293319 date "1993-09-01" @default.
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- W2085293319 title "Structural organization ofMYCN amplicons of neuroblastoma tumors, xenografts, and cell lines characterized by the sequences encompassing theMYCN amplicons in a human neuroblastoma cell line" @default.
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- W2085293319 doi "https://doi.org/10.1002/gcc.2870080104" @default.
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