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• W2085294028 endingPage "569" @default.
• W2085294028 startingPage "564" @default.
• W2085294028 abstract "It has become increasingly apparent of late that inflammation plays an integral role in a spectrum of malignancies including cholangiocarcinoma (CCA). Primary sclerosing cholangitis with chronic inflammation is the most common risk factor for CCA in the Western world. Recent work has highlighted that inflammatory pathways are essential in carcinogenesis and tissue invasion and migration. Inflammation advances carcinogenesis by induction of DNA damage, evasion of apoptosis, promotion of cell proliferation, and neoangiogenesis. CCA is characterized by the presence of a desmoplastic stroma consisting of cancer-associated fibroblasts, tumor-associated macrophages, and tumor-infiltrating lymphocytes. This rich inflammatory milieu is vital to the cancer ecosystem, and targeting its components represents an attractive therapeutic option." @default.
• W2085294028 created "2016-06-24" @default.
• W2085294028 creator A5004470985 @default.
• W2085294028 creator A5042501781 @default.
• W2085294028 date "2014-01-01" @default.
• W2085294028 modified "2023-10-06" @default.
• W2085294028 title "Molecular Pathogenesis of Cholangiocarcinoma" @default.
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• W2085294028 doi "https://doi.org/10.1159/000360502" @default.
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• W2085294028 hasPublicationYear "2014" @default.
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