FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085295654> ?p ?o ?g. }

• W2085295654 endingPage "404" @default.
• W2085295654 startingPage "398" @default.
• W2085295654 abstract "Human umbilical cord mesenchymal stromal cells (hUCMSCs) have recently shown the capacity to differentiate into multiple cell lineages in all three embryonic germ layers. The osteogenic differentiation of hUCMSCs in monolayer culture has been reported, while the differentiation in three-dimensional biomaterials has not yet been reported for tissue-engineering applications. Thus, the aim of this study was to evaluate the feasibility of using hUCMSCs for bone tissue engineering. hUCMSCs were cultured in poly(L-lactic acid) (PLLA) scaffolds in osteogenic medium (OM) for 3 weeks, after which the scaffolds were exposed to several different media, including the OM, a mineralization medium (MM) and the MM with either 10 or 100 ng/ml insulin-like growth factor (IGF)-1. The osteogenic differentiation was confirmed by the up-regulation of Runx2 and OCN, calcium quantification and bone histology. Switching from the OM to the MM promoted collagen synthesis and calcium content per cell, while continuing in the OM retained more cells in the constructs and promoted higher osteogenic gene expression. The addition of IGF-1 into the MM had no effect on cell proliferation, differentiation and matrix synthesis. In conclusion, hUCMSCs show significant potential for bone tissue engineering and culturing in the OM throughout the entire period is beneficial for osteogenic differentiation of these cells." @default.
• W2085295654 created "2016-06-24" @default.
• W2085295654 creator A5044025817 @default.
• W2085295654 creator A5049129841 @default.
• W2085295654 creator A5072880718 @default.
• W2085295654 creator A5083449261 @default.
• W2085295654 date "2009-07-01" @default.
• W2085295654 modified "2023-10-10" @default.
• W2085295654 title "Signalling strategies for osteogenic differentiation of human umbilical cord mesenchymal stromal cells for 3D bone tissue engineering" @default.
• W2085295654 cites W1965599951 @default.
• W2085295654 cites W1973863581 @default.
• W2085295654 cites W1976906682 @default.
• W2085295654 cites W1977950302 @default.
• W2085295654 cites W1981582835 @default.
• W2085295654 cites W1994596418 @default.
• W2085295654 cites W1995833066 @default.
• W2085295654 cites W1996789930 @default.
• W2085295654 cites W1997812904 @default.
• W2085295654 cites W2008673632 @default.
• W2085295654 cites W2021164682 @default.
• W2085295654 cites W2022346732 @default.
• W2085295654 cites W2022482757 @default.
• W2085295654 cites W2027191853 @default.
• W2085295654 cites W2029723752 @default.
• W2085295654 cites W2033498402 @default.
• W2085295654 cites W2034741915 @default.
• W2085295654 cites W2038638882 @default.
• W2085295654 cites W2046095052 @default.
• W2085295654 cites W2046701443 @default.
• W2085295654 cites W2050280695 @default.
• W2085295654 cites W2052052041 @default.
• W2085295654 cites W205534689 @default.
• W2085295654 cites W2055516720 @default.
• W2085295654 cites W2059442046 @default.
• W2085295654 cites W2069387026 @default.
• W2085295654 cites W2071692347 @default.
• W2085295654 cites W2080336305 @default.
• W2085295654 cites W2083245841 @default.
• W2085295654 cites W2090146091 @default.
• W2085295654 cites W2092054789 @default.
• W2085295654 cites W2094810226 @default.
• W2085295654 cites W2095335313 @default.
• W2085295654 cites W2095425438 @default.
• W2085295654 cites W2098512297 @default.
• W2085295654 cites W2102680446 @default.
• W2085295654 cites W2107277218 @default.
• W2085295654 cites W2140542503 @default.
• W2085295654 cites W2159999899 @default.
• W2085295654 cites W2170221113 @default.
• W2085295654 cites W4249994679 @default.
• W2085295654 doi "https://doi.org/10.1002/term.176" @default.
• W2085295654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19434662" @default.
• W2085295654 hasPublicationYear "2009" @default.
• W2085295654 type Work @default.
• W2085295654 sameAs 2085295654 @default.
• W2085295654 citedByCount "61" @default.
• W2085295654 countsByYear W20852956542012 @default.
• W2085295654 countsByYear W20852956542013 @default.
• W2085295654 countsByYear W20852956542014 @default.
• W2085295654 countsByYear W20852956542015 @default.
• W2085295654 countsByYear W20852956542016 @default.
• W2085295654 countsByYear W20852956542017 @default.
• W2085295654 countsByYear W20852956542018 @default.
• W2085295654 countsByYear W20852956542019 @default.
• W2085295654 countsByYear W20852956542020 @default.
• W2085295654 countsByYear W20852956542021 @default.
• W2085295654 countsByYear W20852956542022 @default.
• W2085295654 crossrefType "journal-article" @default.
• W2085295654 hasAuthorship W2085295654A5044025817 @default.
• W2085295654 hasAuthorship W2085295654A5049129841 @default.
• W2085295654 hasAuthorship W2085295654A5072880718 @default.
• W2085295654 hasAuthorship W2085295654A5083449261 @default.
• W2085295654 hasBestOaLocation W20852956541 @default.
• W2085295654 hasConcept C104317684 @default.
• W2085295654 hasConcept C119577978 @default.
• W2085295654 hasConcept C136229726 @default.
• W2085295654 hasConcept C148738053 @default.
• W2085295654 hasConcept C16930146 @default.
• W2085295654 hasConcept C185592680 @default.
• W2085295654 hasConcept C198826908 @default.
• W2085295654 hasConcept C202751555 @default.
• W2085295654 hasConcept C203014093 @default.
• W2085295654 hasConcept C2776363554 @default.
• W2085295654 hasConcept C2776955114 @default.
• W2085295654 hasConcept C2778260815 @default.
• W2085295654 hasConcept C2778606738 @default.
• W2085295654 hasConcept C49892992 @default.
• W2085295654 hasConcept C502942594 @default.
• W2085295654 hasConcept C55493867 @default.
• W2085295654 hasConcept C71924100 @default.
• W2085295654 hasConcept C86803240 @default.
• W2085295654 hasConcept C95444343 @default.
• W2085295654 hasConceptScore W2085295654C104317684 @default.
• W2085295654 hasConceptScore W2085295654C119577978 @default.
• W2085295654 hasConceptScore W2085295654C136229726 @default.
• W2085295654 hasConceptScore W2085295654C148738053 @default.
• W2085295654 hasConceptScore W2085295654C16930146 @default.
• W2085295654 hasConceptScore W2085295654C185592680 @default.

• next