FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085305468> ?p ?o ?g. }

• W2085305468 endingPage "5544" @default.
• W2085305468 startingPage "5537" @default.
• W2085305468 abstract "Microcephalin (MCPH1/BRIT1) is a potential tumour suppressor that localizes to the centrosome, forms ionizing radiation-induced nuclear foci (IRIF) and is involved in the DNA damage checkpoints that ensure genome stability. Here, we report the impact of Mcph1 disruption in the hyper-recombinogenic DT40 cell line. Mcph1(-/-) cells were viable and proliferated at the same rate as wild-type controls. Mcph1-deficient cells had intact G2-to-M checkpoint responses after ionizing radiation (IR) treatment, but showed moderate radiosensitivity. Light and electron microscopy indicated normal centrosome structures in Mcph1 null cells, but IR induced massive amplification of centrosome numbers in the absence of Mcph1. Mcph1 null cells formed γ-H2AX and Rad51 IRIF, but resolved them more slowly than wild-type cells. Mcph1 deficiency caused sustained Chk1 phosphorylation after IR, dysregulating Cdk2 activity. These findings show that Mcph1 controls centrosome numbers after DNA damage, which may indicate a novel tumour suppressive mechanism for microcephalin." @default.
• W2085305468 created "2016-06-24" @default.
• W2085305468 creator A5003555440 @default.
• W2085305468 creator A5019091122 @default.
• W2085305468 creator A5041325599 @default.
• W2085305468 creator A5043304411 @default.
• W2085305468 creator A5045857608 @default.
• W2085305468 date "2010-07-26" @default.
• W2085305468 modified "2023-10-18" @default.
• W2085305468 title "MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification" @default.
• W2085305468 cites W1963815543 @default.
• W2085305468 cites W1992425431 @default.
• W2085305468 cites W1993672313 @default.
• W2085305468 cites W2007025382 @default.
• W2085305468 cites W2013826273 @default.
• W2085305468 cites W2019271191 @default.
• W2085305468 cites W2020329784 @default.
• W2085305468 cites W2025829112 @default.
• W2085305468 cites W2025887362 @default.
• W2085305468 cites W2027784327 @default.
• W2085305468 cites W2038889791 @default.
• W2085305468 cites W2058800908 @default.
• W2085305468 cites W2059971436 @default.
• W2085305468 cites W2066362104 @default.
• W2085305468 cites W2072637746 @default.
• W2085305468 cites W2076317616 @default.
• W2085305468 cites W2082559623 @default.
• W2085305468 cites W2089371078 @default.
• W2085305468 cites W2100112739 @default.
• W2085305468 cites W2103762819 @default.
• W2085305468 cites W2107073856 @default.
• W2085305468 cites W2115123726 @default.
• W2085305468 cites W2134590240 @default.
• W2085305468 cites W2144717507 @default.
• W2085305468 cites W2145200068 @default.
• W2085305468 cites W2157963865 @default.
• W2085305468 cites W2158160769 @default.
• W2085305468 cites W2158266210 @default.
• W2085305468 cites W2158805631 @default.
• W2085305468 cites W2162311131 @default.
• W2085305468 cites W2166053174 @default.
• W2085305468 cites W2166489903 @default.
• W2085305468 cites W2171435189 @default.
• W2085305468 cites W40197506 @default.
• W2085305468 doi "https://doi.org/10.1038/onc.2010.302" @default.
• W2085305468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20661222" @default.
• W2085305468 hasPublicationYear "2010" @default.
• W2085305468 type Work @default.
• W2085305468 sameAs 2085305468 @default.
• W2085305468 citedByCount "29" @default.
• W2085305468 countsByYear W20853054682012 @default.
• W2085305468 countsByYear W20853054682013 @default.
• W2085305468 countsByYear W20853054682014 @default.
• W2085305468 countsByYear W20853054682015 @default.
• W2085305468 countsByYear W20853054682016 @default.
• W2085305468 countsByYear W20853054682017 @default.
• W2085305468 countsByYear W20853054682018 @default.
• W2085305468 countsByYear W20853054682019 @default.
• W2085305468 countsByYear W20853054682020 @default.
• W2085305468 countsByYear W20853054682021 @default.
• W2085305468 countsByYear W20853054682022 @default.
• W2085305468 crossrefType "journal-article" @default.
• W2085305468 hasAuthorship W2085305468A5003555440 @default.
• W2085305468 hasAuthorship W2085305468A5019091122 @default.
• W2085305468 hasAuthorship W2085305468A5041325599 @default.
• W2085305468 hasAuthorship W2085305468A5043304411 @default.
• W2085305468 hasAuthorship W2085305468A5045857608 @default.
• W2085305468 hasBestOaLocation W20853054681 @default.
• W2085305468 hasConcept C10447061 @default.
• W2085305468 hasConcept C105696609 @default.
• W2085305468 hasConcept C111337013 @default.
• W2085305468 hasConcept C121332964 @default.
• W2085305468 hasConcept C134935766 @default.
• W2085305468 hasConcept C143425029 @default.
• W2085305468 hasConcept C153911025 @default.
• W2085305468 hasConcept C178169997 @default.
• W2085305468 hasConcept C18231593 @default.
• W2085305468 hasConcept C185544564 @default.
• W2085305468 hasConcept C190283241 @default.
• W2085305468 hasConcept C2779012473 @default.
• W2085305468 hasConcept C29537977 @default.
• W2085305468 hasConcept C50001416 @default.
• W2085305468 hasConcept C502942594 @default.
• W2085305468 hasConcept C54355233 @default.
• W2085305468 hasConcept C552990157 @default.
• W2085305468 hasConcept C86803240 @default.
• W2085305468 hasConcept C95444343 @default.
• W2085305468 hasConceptScore W2085305468C10447061 @default.
• W2085305468 hasConceptScore W2085305468C105696609 @default.
• W2085305468 hasConceptScore W2085305468C111337013 @default.
• W2085305468 hasConceptScore W2085305468C121332964 @default.
• W2085305468 hasConceptScore W2085305468C134935766 @default.
• W2085305468 hasConceptScore W2085305468C143425029 @default.
• W2085305468 hasConceptScore W2085305468C153911025 @default.
• W2085305468 hasConceptScore W2085305468C178169997 @default.
• W2085305468 hasConceptScore W2085305468C18231593 @default.
• W2085305468 hasConceptScore W2085305468C185544564 @default.
• W2085305468 hasConceptScore W2085305468C190283241 @default.

• next