Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085306175> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2085306175 abstract "Introduction: Estrogen receptor coregulator over-expression promotes carcinogenesis and/or progression of endocrine related-cancers where steroid hormones are powerful mitogenic agents. Recent studies in our laboratory as well as others demonstrated that PELP1 is a proto-oncogene and a prognostic indicator of decreased survival in breast cancer patients. Recent studies indicated that PELP1 is needed for optimal epigenetic modifications at ER target genes and PELP1 interactions with KDM1 play a key role in PELP1 mediated oncogenic functions. However, the in vivo significance of PELP1 deregulation during initiation and progression of breast cancer remains unknown. The objective of this study is determine the molecular mechanisms by which PELP1 regulate breast cancer progression in vivo. Method: To determine the significance of PELP1 over-expression in mammary tumorigenesis, we used an inducible, tissue-specific PELP1 expressing transgenic mouse. Mammary epithelial-specific expression of PELP1 was validated by immunohistochemistry and Western blot analysis. PELP1-mediated morphological and histological changes were analyzed by examining carmine-stained whole mounts and HE73(24 Suppl): Abstract nr P2-05-01." @default.
- W2085306175 created "2016-06-24" @default.
- W2085306175 creator A5045482923 @default.
- W2085306175 creator A5068958564 @default.
- W2085306175 creator A5080050605 @default.
- W2085306175 creator A5083785629 @default.
- W2085306175 creator A5089505186 @default.
- W2085306175 date "2013-12-15" @default.
- W2085306175 modified "2023-09-27" @default.
- W2085306175 title "Abstract P2-05-01: Induction of PELP1 expression in mammary gland promotes tumorigenesis by enhancing CDK-CyclinD1 signaling" @default.
- W2085306175 doi "https://doi.org/10.1158/0008-5472.sabcs13-p2-05-01" @default.
- W2085306175 hasPublicationYear "2013" @default.
- W2085306175 type Work @default.
- W2085306175 sameAs 2085306175 @default.
- W2085306175 citedByCount "0" @default.
- W2085306175 crossrefType "proceedings-article" @default.
- W2085306175 hasAuthorship W2085306175A5045482923 @default.
- W2085306175 hasAuthorship W2085306175A5068958564 @default.
- W2085306175 hasAuthorship W2085306175A5080050605 @default.
- W2085306175 hasAuthorship W2085306175A5083785629 @default.
- W2085306175 hasAuthorship W2085306175A5089505186 @default.
- W2085306175 hasConcept C121608353 @default.
- W2085306175 hasConcept C126322002 @default.
- W2085306175 hasConcept C150903083 @default.
- W2085306175 hasConcept C203014093 @default.
- W2085306175 hasConcept C204232928 @default.
- W2085306175 hasConcept C207001950 @default.
- W2085306175 hasConcept C2778001805 @default.
- W2085306175 hasConcept C2781018059 @default.
- W2085306175 hasConcept C29537977 @default.
- W2085306175 hasConcept C502942594 @default.
- W2085306175 hasConcept C530470458 @default.
- W2085306175 hasConcept C555283112 @default.
- W2085306175 hasConcept C71924100 @default.
- W2085306175 hasConcept C84606932 @default.
- W2085306175 hasConcept C86803240 @default.
- W2085306175 hasConceptScore W2085306175C121608353 @default.
- W2085306175 hasConceptScore W2085306175C126322002 @default.
- W2085306175 hasConceptScore W2085306175C150903083 @default.
- W2085306175 hasConceptScore W2085306175C203014093 @default.
- W2085306175 hasConceptScore W2085306175C204232928 @default.
- W2085306175 hasConceptScore W2085306175C207001950 @default.
- W2085306175 hasConceptScore W2085306175C2778001805 @default.
- W2085306175 hasConceptScore W2085306175C2781018059 @default.
- W2085306175 hasConceptScore W2085306175C29537977 @default.
- W2085306175 hasConceptScore W2085306175C502942594 @default.
- W2085306175 hasConceptScore W2085306175C530470458 @default.
- W2085306175 hasConceptScore W2085306175C555283112 @default.
- W2085306175 hasConceptScore W2085306175C71924100 @default.
- W2085306175 hasConceptScore W2085306175C84606932 @default.
- W2085306175 hasConceptScore W2085306175C86803240 @default.
- W2085306175 hasLocation W20853061751 @default.
- W2085306175 hasOpenAccess W2085306175 @default.
- W2085306175 hasPrimaryLocation W20853061751 @default.
- W2085306175 hasRelatedWork W1968773294 @default.
- W2085306175 hasRelatedWork W1988435124 @default.
- W2085306175 hasRelatedWork W1994517409 @default.
- W2085306175 hasRelatedWork W2023958693 @default.
- W2085306175 hasRelatedWork W2040648628 @default.
- W2085306175 hasRelatedWork W2043794121 @default.
- W2085306175 hasRelatedWork W2091632974 @default.
- W2085306175 hasRelatedWork W2102803803 @default.
- W2085306175 hasRelatedWork W2324956015 @default.
- W2085306175 hasRelatedWork W2327322180 @default.
- W2085306175 hasRelatedWork W2330817355 @default.
- W2085306175 hasRelatedWork W2334392410 @default.
- W2085306175 hasRelatedWork W2337875469 @default.
- W2085306175 hasRelatedWork W2560278414 @default.
- W2085306175 hasRelatedWork W2740756701 @default.
- W2085306175 hasRelatedWork W2886899594 @default.
- W2085306175 hasRelatedWork W3048066804 @default.
- W2085306175 hasRelatedWork W3131745481 @default.
- W2085306175 hasRelatedWork W596318092 @default.
- W2085306175 hasRelatedWork W94760739 @default.
- W2085306175 isParatext "false" @default.
- W2085306175 isRetracted "false" @default.
- W2085306175 magId "2085306175" @default.
- W2085306175 workType "article" @default.