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- W2085307258 abstract "The transcription factor FAST-1 has recently been shown to play a key role in the specification of mesoderm by TGFβ superfamily signals in the early Xenopus embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and characterized its expression during embryogenesis and function in activin/TGFβ signal transduction. In vitro, Fast1 associates with Smads in response to an activin/TGFβ signal to form a complex that recognizes the Xenopus activin responsive element (ARE) targeted by Xenopus FAST-1. In intact cells, introduction of Fast1 confers activin/TGFβ regulation of an ARE-luciferase reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast before gastrulation and declines as development progresses. We propose that mouse Fast1, like Xenopus FAST-1, mediates TGFβ superfamily signals specifying developmental fate during early embryogenesis." @default.
- W2085307258 created "2016-06-24" @default.
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- W2085307258 date "1998-12-01" @default.
- W2085307258 modified "2023-09-27" @default.
- W2085307258 title "A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis" @default.
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- W2085307258 doi "https://doi.org/10.1016/s0925-4773(98)00160-9" @default.
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