FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085319763> ?p ?o ?g. }

• W2085319763 endingPage "454" @default.
• W2085319763 startingPage "449" @default.
• W2085319763 abstract "Purpose To study the effect of hydrogen peroxide (H2O2) on radiation-induced apoptosis in human prostate cancer PC-3 cells. Methods and Materials At 4h before the irradiation, PC-3 cells were exposed to 10mM ammonium chloride (NH4Cl) concentrations. Subsequently, cells were exposed to 0.1mM H2O2 just before the irradiations, which were administered with 10-MV X-rays at doses of 10Gy. Results The percentage of apoptotic cells at 48h after X-irradiation alone, H2O2 alone, and combined X-irradiation and H2O2 was 1.85%, 4.85%, and 28.4%, respectively. With use of combined X-irradiation and H2O2, production of reactive oxygen species (ROS) occurred 4h after the irradiation. This resulted in lysosomal rupturing, mitochondrial fragmentation, and the release of cytochrome c into the cytoplasm from the mitochondria. In contrast, when cells were exposed to NH4Cl before the X-irradiation and H2O2 administration, apoptosis was almost completely suppressed, ROS production did not occur, lysosomal rupture and mitochondrial fragmentation were blocked, and cytochrome c was not released. Conclusions Hydrogen peroxide strongly enhanced lysosome-dependent radiation-induced apoptosis in human prostate cancer PC-3 cells. A combined use of X-rays and H2O2 can also injure the mitochondrial cytoplasmic organelles and lead to the production of ROS that in and of itself might possibly induce apoptosis. To study the effect of hydrogen peroxide (H2O2) on radiation-induced apoptosis in human prostate cancer PC-3 cells. At 4h before the irradiation, PC-3 cells were exposed to 10mM ammonium chloride (NH4Cl) concentrations. Subsequently, cells were exposed to 0.1mM H2O2 just before the irradiations, which were administered with 10-MV X-rays at doses of 10Gy. The percentage of apoptotic cells at 48h after X-irradiation alone, H2O2 alone, and combined X-irradiation and H2O2 was 1.85%, 4.85%, and 28.4%, respectively. With use of combined X-irradiation and H2O2, production of reactive oxygen species (ROS) occurred 4h after the irradiation. This resulted in lysosomal rupturing, mitochondrial fragmentation, and the release of cytochrome c into the cytoplasm from the mitochondria. In contrast, when cells were exposed to NH4Cl before the X-irradiation and H2O2 administration, apoptosis was almost completely suppressed, ROS production did not occur, lysosomal rupture and mitochondrial fragmentation were blocked, and cytochrome c was not released. Hydrogen peroxide strongly enhanced lysosome-dependent radiation-induced apoptosis in human prostate cancer PC-3 cells. A combined use of X-rays and H2O2 can also injure the mitochondrial cytoplasmic organelles and lead to the production of ROS that in and of itself might possibly induce apoptosis." @default.
• W2085319763 created "2016-06-24" @default.
• W2085319763 creator A5003857344 @default.
• W2085319763 creator A5024590817 @default.
• W2085319763 creator A5029797576 @default.
• W2085319763 creator A5051964869 @default.
• W2085319763 creator A5053900220 @default.
• W2085319763 creator A5058887036 @default.
• W2085319763 creator A5067227542 @default.
• W2085319763 date "2009-10-01" @default.
• W2085319763 modified "2023-10-17" @default.
• W2085319763 title "Combination Treatment of Hydrogen Peroxide and X-Rays Induces Apoptosis in Human Prostate Cancer PC-3 Cells" @default.
• W2085319763 cites W1568529372 @default.
• W2085319763 cites W1811191752 @default.
• W2085319763 cites W1825915710 @default.
• W2085319763 cites W2019872821 @default.
• W2085319763 cites W2028520206 @default.
• W2085319763 cites W2028585334 @default.
• W2085319763 cites W2030723908 @default.
• W2085319763 cites W2038108154 @default.
• W2085319763 cites W2046646032 @default.
• W2085319763 cites W2048569323 @default.
• W2085319763 cites W2050420714 @default.
• W2085319763 cites W2053174155 @default.
• W2085319763 cites W2056643793 @default.
• W2085319763 cites W2074421032 @default.
• W2085319763 cites W2075749235 @default.
• W2085319763 cites W2075757507 @default.
• W2085319763 cites W2130935668 @default.
• W2085319763 cites W2137199906 @default.
• W2085319763 cites W2144498681 @default.
• W2085319763 cites W2148700883 @default.
• W2085319763 cites W2163120057 @default.
• W2085319763 cites W4243767567 @default.
• W2085319763 cites W1849608747 @default.
• W2085319763 doi "https://doi.org/10.1016/j.ijrobp.2009.04.092" @default.
• W2085319763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19735867" @default.
• W2085319763 hasPublicationYear "2009" @default.
• W2085319763 type Work @default.
• W2085319763 sameAs 2085319763 @default.
• W2085319763 citedByCount "35" @default.
• W2085319763 countsByYear W20853197632013 @default.
• W2085319763 countsByYear W20853197632014 @default.
• W2085319763 countsByYear W20853197632015 @default.
• W2085319763 countsByYear W20853197632016 @default.
• W2085319763 countsByYear W20853197632017 @default.
• W2085319763 countsByYear W20853197632018 @default.
• W2085319763 countsByYear W20853197632019 @default.
• W2085319763 countsByYear W20853197632020 @default.
• W2085319763 countsByYear W20853197632021 @default.
• W2085319763 countsByYear W20853197632022 @default.
• W2085319763 countsByYear W20853197632023 @default.
• W2085319763 crossrefType "journal-article" @default.
• W2085319763 hasAuthorship W2085319763A5003857344 @default.
• W2085319763 hasAuthorship W2085319763A5024590817 @default.
• W2085319763 hasAuthorship W2085319763A5029797576 @default.
• W2085319763 hasAuthorship W2085319763A5051964869 @default.
• W2085319763 hasAuthorship W2085319763A5053900220 @default.
• W2085319763 hasAuthorship W2085319763A5058887036 @default.
• W2085319763 hasAuthorship W2085319763A5067227542 @default.
• W2085319763 hasConcept C121608353 @default.
• W2085319763 hasConcept C126322002 @default.
• W2085319763 hasConcept C153911025 @default.
• W2085319763 hasConcept C185592680 @default.
• W2085319763 hasConcept C18903297 @default.
• W2085319763 hasConcept C190283241 @default.
• W2085319763 hasConcept C191015642 @default.
• W2085319763 hasConcept C28859421 @default.
• W2085319763 hasConcept C29311851 @default.
• W2085319763 hasConcept C31573885 @default.
• W2085319763 hasConcept C43759708 @default.
• W2085319763 hasConcept C48349386 @default.
• W2085319763 hasConcept C502942594 @default.
• W2085319763 hasConcept C533411734 @default.
• W2085319763 hasConcept C55493867 @default.
• W2085319763 hasConcept C71924100 @default.
• W2085319763 hasConcept C86803240 @default.
• W2085319763 hasConcept C95444343 @default.
• W2085319763 hasConcept C96232424 @default.
• W2085319763 hasConceptScore W2085319763C121608353 @default.
• W2085319763 hasConceptScore W2085319763C126322002 @default.
• W2085319763 hasConceptScore W2085319763C153911025 @default.
• W2085319763 hasConceptScore W2085319763C185592680 @default.
• W2085319763 hasConceptScore W2085319763C18903297 @default.
• W2085319763 hasConceptScore W2085319763C190283241 @default.
• W2085319763 hasConceptScore W2085319763C191015642 @default.
• W2085319763 hasConceptScore W2085319763C28859421 @default.
• W2085319763 hasConceptScore W2085319763C29311851 @default.
• W2085319763 hasConceptScore W2085319763C31573885 @default.
• W2085319763 hasConceptScore W2085319763C43759708 @default.
• W2085319763 hasConceptScore W2085319763C48349386 @default.
• W2085319763 hasConceptScore W2085319763C502942594 @default.
• W2085319763 hasConceptScore W2085319763C533411734 @default.
• W2085319763 hasConceptScore W2085319763C55493867 @default.
• W2085319763 hasConceptScore W2085319763C71924100 @default.
• W2085319763 hasConceptScore W2085319763C86803240 @default.
• W2085319763 hasConceptScore W2085319763C95444343 @default.
• W2085319763 hasConceptScore W2085319763C96232424 @default.

• next