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- W2085321346 abstract "Background: Recent observations from different parts of world as confirmed the existence of severe P.vivaxmalaria, however, the eports of severity in children are scanty. Methods: This prospective study was conducted on 168 admited children ofmalaria during January 2011 toDecember 2011 in in edical college hospital, Bikaner (Northwest India). Species diagosiswas donebyperipheral blood smear and rapid diagnostic test. urther confirmation of severe P.vivax monoinfection was done y polymerase chain reaction revealing 96.38% accuracy. Severe alaria was defined strictly on WHO criteria (2000). Results: The proportion of P.falciparum,P.vivax, and mixed nfection (P.falciparum and P.vivax) was 34.5%, 53.6%, and 11.9%, espectively. Severe malaria was detected in 47.6% (80/168) hildren, with the risk greatest among P.vivax monoinfection 62.2% [56/90]) compared with P.falciparum, either alone (34.5% 20/58]; OR=3.1 [95% CI =1.49–6.62], p =0.001) or mixed infecions (20% [4/20]; OR=6.59 [95% CI =1.85–25.64]). In children<5 ears of age, the proportion of severe malaria attributable to .vivax rose to 69.2% (18/26) compared with 26.9% (7/26) of .falciparum(OR=6.12 [95% CI =1.58–24.79], p =0.005) and 3.85% 1/26) of mixed infection (OR=56.25 [95% CI =6.00–1322.27], < 0.0001). The proportion of children having severe manifestaions, which included severe anemia, thrombocytopenia, cerebral alaria, acute respiratory distress syndrome, hepatic dysfunction, enal dysfunction, abnormal bleeding, shock and hemoglobinuria, as significantly high in association with P.vivax monoinfection n 0–5 year age group, while the same was significantly high n association with P.falciparum monoinfection in 5–10 year age roup. Similarly P.vivax monoinfection had greatest propensity to ause multiorgan dysfunction in 0–5 year age group (38.9% [7/18], < 0.01) in comparison to P.falciparum monoinfection, which had imilar propensity in 5–10year age group (66.7% [6/9],p =0.03). The ase fatality rate of severe P.vivax monoinfection was 2.8% versus .6% of severe P.falciparum monoinfection (p=1.0). Conclusion: This study reaffirms the evidence of severe P.vivax onoinfection in children in Bikaner having almost similar specrum to P.falciparum monoinfection." @default.
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- W2085321346 date "2012-06-01" @default.
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- W2085321346 title "Purifying selection in the evolution of dengue virus type 1 in Malaysia" @default.
- W2085321346 doi "https://doi.org/10.1016/j.ijid.2012.05.930" @default.
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