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- W2085326265 abstract "The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effects on the regulation of the proliferation, the differentiation, and the viability of leukemic cells. The translocation can be detected as the only genetic abnormality or as part of more complex abnormalities. If t(8;21) is detected in a patient with bone marrow pathology, the diagnosis AML can be made based on this abnormality alone. t(8;21) is usually associated with a good prognosis. Whether the detection of the fusion gene can be used for evaluation of minimal residual disease and risk of leukemia relapse remains to be clarified. To conclude, detection of t(8;21) is essential for optimal handling of these patients as it has both diagnostic, prognostic, and therapeutic implications." @default.
- W2085326265 created "2016-06-24" @default.
- W2085326265 creator A5021294750 @default.
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- W2085326265 creator A5058990785 @default.
- W2085326265 creator A5074974438 @default.
- W2085326265 creator A5078913930 @default.
- W2085326265 date "2011-01-01" @default.
- W2085326265 modified "2023-10-10" @default.
- W2085326265 title "Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications" @default.
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