Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085331370> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2085331370 abstract "Omeprazole increases circulating gastrin levels, which in turn may affect the growth and differentiation of colon mucosa. Chloride transport mechanisms in normal colon were analyzed as markers for possible trophic actions of endogenous hypergastrinemia.Four groups of Fischer rats were studied for 10 days. Group 1 (baseline) received no treatment. Group 2 received omeprazole only. Group 3 received omeprazole plus vehicle. Group 4 received omeprazole plus CCK-B gastrin receptor antagonist (GRA) L740,093 in vehicle. On day 10 serum gastrin was assayed. Colon mucosa was analyzed for protein and DNA content. Semiquantitative Northern analysis measured levels of messenger RNA (mRNA) encoding for key Cl- transporters: Na-K-Cl cotransporter (Cl- secretion in crypts), Cl-/HCO3- exchanger (Cl- absorption in villi), and Na/K adenosine triphosphatase (not directly involved in Cl- transport).Omeprazole increased gastrin levels, which were not altered by vehicle or GRA. Omeprazole increased protein, DNA, and Na/K adenosine triphosphatase mRNA levels, with no effect by GRA. In contrast, omeprazole decreased Na-K-Cl and Cl-/HCO3- mRNA levels, effects that were partly reversed by GRA.Omeprazole augments growth index values of colon mucosa independent of serum gastrin. Against a background of omeprazole-induced achlorhydria hypergastrinemia appears to influence differentiation rather than growth of normal colon mucosa." @default.
- W2085331370 created "2016-06-24" @default.
- W2085331370 creator A5031041121 @default.
- W2085331370 creator A5036946856 @default.
- W2085331370 creator A5055037445 @default.
- W2085331370 creator A5057978103 @default.
- W2085331370 creator A5088649225 @default.
- W2085331370 date "1999-08-01" @default.
- W2085331370 modified "2023-09-26" @default.
- W2085331370 title "Gastrin-mediated effects of omeprazole on rat colon mucosa" @default.
- W2085331370 cites W1173533284 @default.
- W2085331370 cites W1546941284 @default.
- W2085331370 cites W1775749144 @default.
- W2085331370 cites W1874353661 @default.
- W2085331370 cites W1982972448 @default.
- W2085331370 cites W2028502696 @default.
- W2085331370 cites W2028706407 @default.
- W2085331370 cites W2029133566 @default.
- W2085331370 cites W2029989332 @default.
- W2085331370 cites W2045027411 @default.
- W2085331370 cites W2051680485 @default.
- W2085331370 cites W2078844281 @default.
- W2085331370 cites W2117213772 @default.
- W2085331370 cites W4238407188 @default.
- W2085331370 cites W4239203599 @default.
- W2085331370 cites W4294216491 @default.
- W2085331370 cites W93255434 @default.
- W2085331370 doi "https://doi.org/10.1016/s0039-6060(99)70165-0" @default.
- W2085331370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10455894" @default.
- W2085331370 hasPublicationYear "1999" @default.
- W2085331370 type Work @default.
- W2085331370 sameAs 2085331370 @default.
- W2085331370 citedByCount "16" @default.
- W2085331370 countsByYear W20853313702012 @default.
- W2085331370 countsByYear W20853313702015 @default.
- W2085331370 countsByYear W20853313702016 @default.
- W2085331370 crossrefType "journal-article" @default.
- W2085331370 hasAuthorship W2085331370A5031041121 @default.
- W2085331370 hasAuthorship W2085331370A5036946856 @default.
- W2085331370 hasAuthorship W2085331370A5055037445 @default.
- W2085331370 hasAuthorship W2085331370A5057978103 @default.
- W2085331370 hasAuthorship W2085331370A5088649225 @default.
- W2085331370 hasConcept C126322002 @default.
- W2085331370 hasConcept C134018914 @default.
- W2085331370 hasConcept C170493617 @default.
- W2085331370 hasConcept C185592680 @default.
- W2085331370 hasConcept C2776885963 @default.
- W2085331370 hasConcept C2776986829 @default.
- W2085331370 hasConcept C2777498785 @default.
- W2085331370 hasConcept C2779422922 @default.
- W2085331370 hasConcept C2781443798 @default.
- W2085331370 hasConcept C3019368612 @default.
- W2085331370 hasConcept C49039625 @default.
- W2085331370 hasConcept C71924100 @default.
- W2085331370 hasConceptScore W2085331370C126322002 @default.
- W2085331370 hasConceptScore W2085331370C134018914 @default.
- W2085331370 hasConceptScore W2085331370C170493617 @default.
- W2085331370 hasConceptScore W2085331370C185592680 @default.
- W2085331370 hasConceptScore W2085331370C2776885963 @default.
- W2085331370 hasConceptScore W2085331370C2776986829 @default.
- W2085331370 hasConceptScore W2085331370C2777498785 @default.
- W2085331370 hasConceptScore W2085331370C2779422922 @default.
- W2085331370 hasConceptScore W2085331370C2781443798 @default.
- W2085331370 hasConceptScore W2085331370C3019368612 @default.
- W2085331370 hasConceptScore W2085331370C49039625 @default.
- W2085331370 hasConceptScore W2085331370C71924100 @default.
- W2085331370 hasLocation W20853313701 @default.
- W2085331370 hasLocation W20853313702 @default.
- W2085331370 hasOpenAccess W2085331370 @default.
- W2085331370 hasPrimaryLocation W20853313701 @default.
- W2085331370 hasRelatedWork W2033322586 @default.
- W2085331370 hasRelatedWork W2059057112 @default.
- W2085331370 hasRelatedWork W2069633620 @default.
- W2085331370 hasRelatedWork W2085201078 @default.
- W2085331370 hasRelatedWork W2087449639 @default.
- W2085331370 hasRelatedWork W2417577765 @default.
- W2085331370 hasRelatedWork W2438444554 @default.
- W2085331370 hasRelatedWork W2588689638 @default.
- W2085331370 hasRelatedWork W2748952813 @default.
- W2085331370 hasRelatedWork W4238501047 @default.
- W2085331370 isParatext "false" @default.
- W2085331370 isRetracted "false" @default.
- W2085331370 magId "2085331370" @default.
- W2085331370 workType "article" @default.