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- W2085333876 abstract "Introduction. Hypothermia is a robust neuroprotective strategy in experimental models of cerebral injury. The purpose of this study was to determine if hypothermia decreases neurocognitive dysfunction after coronary artery bypass graft surgery (CABG). Methods. After Internal Review Board approval and informed consent, 227 patients undergoing CABG surgery were prospectively enrolled and randomly assigned to either normothermic (35.5 to 36.5°C) or hypothermic (28 to 30°C) cardiopulmonary bypass. Neurologic and neurocognitive testing was performed preoperatively, 3 to 5 days postoperatively, and 6 weeks after CABG. Postoperative neurologic dysfunction was defined as a ≥ 2-point decrease from baseline on the Western Perioperative Neurologic Scale. Cognitive Index, defined as a change in any of four distinct cognitive domains identified using factor analysis, was compared between two groups at 6 weeks by using multivariate linear regression. Results. There were no statistically significant differences in either neurologic or neurocognitive performance between groups in a multivariable model adjusting for covariable effects of baseline cognitive function, age, and years of education. Conclusions. In this well-controlled study of temperature management, we demonstrated that hypothermia offered no apparent neuroprotection during CPB. Issues. cardiopulmonary bypass, temperature management, and neuroprotection." @default.
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- W2085333876 date "2000-11-01" @default.
- W2085333876 modified "2023-09-26" @default.
- W2085333876 title "A prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cerebral outcome after coronary artery bypass grafting" @default.
- W2085333876 doi "https://doi.org/10.1016/s0003-4975(00)02120-2" @default.
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