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• W2085336728 endingPage "15394" @default.
• W2085336728 startingPage "15388" @default.
• W2085336728 abstract "The thermal stability and folding kinetics of a 15-residue beta-hairpin (SESYINPDGTWTVTE) have been studied by using infrared (IR) spectroscopy coupled with laser-induced temperature-jump (T-jump) technique for rapid folding-unfolding initiation. An alternative method based on analyzing IR difference spectra was also introduced to obtain thermodynamic properties of beta-sheets, which complements the commonly used circular dichroism (CD) and fluorescence techniques. Equilibrium IR measurements indicate that the thermal unfolding of this beta-hairpin is fairly broad. However, it can be described by a two-state transition with a thermal melting temperature of approximately 29 degrees C. Time-resolved IR measurements following a T-jump, probed at 1634 cm(-1), indicate that the folding of this beta-hairpin follows first-order kinetics and is amazingly fast. At 300 K, the folding time is approximately 0.8 micros, which is only 2-3 times slower than that of alpha-helix formation. Additionally, the energetic barrier for folding is small (approximately 2 kcal mol(-1)). These results, in conjunction with results from other studies, support a view that the details of native contacts play a dominant role in the kinetics of beta-hairpin folding." @default.
• W2085336728 created "2016-06-24" @default.
• W2085336728 creator A5004998219 @default.
• W2085336728 creator A5015329154 @default.
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• W2085336728 date "2003-11-20" @default.
• W2085336728 modified "2023-10-16" @default.
• W2085336728 title "Infrared Study of the Stability and Folding Kinetics of a 15-Residue <i>β</i>-Hairpin" @default.
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• W2085336728 doi "https://doi.org/10.1021/ja037053b" @default.
• W2085336728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14664583" @default.
• W2085336728 hasPublicationYear "2003" @default.
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