Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085338735> ?p ?o ?g. }
- W2085338735 endingPage "950" @default.
- W2085338735 startingPage "940" @default.
- W2085338735 abstract "A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe and stable formulation for the treatment of leishmaniasis. The loading of AmB in the complex was in the range of ∼20–50%. AmB was in a highly aggregated state with an aggregation ratio often above 2.0. This complex (AmB–PGA) was shown to be stable and to have reduced toxicity to human red blood cells and KB cells compared to the parent compound; cell viability was not affected at an AmB concentration as high as 50 and 200 μg/mL respectively. This AmB–PGA complex retained AmB activity against intracellular Leishmania major amastigotes in the differentiated THP-1 cells with an EC50 of 0.07 ± 0.03–0.08 ± 0.01 μg/mL, which is similar to Fungizone (EC50 of 0.06 ± 0.01 μg/mL). The in vitro antileishmanial activity of the complex against Leishmania donovani was retained after storage at 37 °C for 7 days in the form of a solution (EC50 of 0.27 ± 0.03 to 0.35 ± 0.04 μg/mL) and for 30 days as a solid (EC50 of 0.41 ± 0.07 to 0.63 ± 0.25 μg/mL). These encouraging results indicate that the AmB–PGA complex has the potential for further development." @default.
- W2085338735 created "2016-06-24" @default.
- W2085338735 creator A5020960555 @default.
- W2085338735 creator A5022355905 @default.
- W2085338735 creator A5034378141 @default.
- W2085338735 creator A5052363075 @default.
- W2085338735 creator A5053604740 @default.
- W2085338735 date "2013-02-08" @default.
- W2085338735 modified "2023-09-27" @default.
- W2085338735 title "Noncovalent Complexation of Amphotericin-B with Poly(α-glutamic acid)" @default.
- W2085338735 cites W1568412294 @default.
- W2085338735 cites W1582768911 @default.
- W2085338735 cites W1833793080 @default.
- W2085338735 cites W1964303020 @default.
- W2085338735 cites W1965063429 @default.
- W2085338735 cites W1966469295 @default.
- W2085338735 cites W1966822741 @default.
- W2085338735 cites W1970287198 @default.
- W2085338735 cites W1970635198 @default.
- W2085338735 cites W1972348350 @default.
- W2085338735 cites W1974273412 @default.
- W2085338735 cites W1974920077 @default.
- W2085338735 cites W1977237832 @default.
- W2085338735 cites W1977337492 @default.
- W2085338735 cites W1978507392 @default.
- W2085338735 cites W1979631338 @default.
- W2085338735 cites W1988014109 @default.
- W2085338735 cites W1993416829 @default.
- W2085338735 cites W1994748323 @default.
- W2085338735 cites W1994998334 @default.
- W2085338735 cites W1995591348 @default.
- W2085338735 cites W1996094668 @default.
- W2085338735 cites W2001273171 @default.
- W2085338735 cites W2008221802 @default.
- W2085338735 cites W2009689217 @default.
- W2085338735 cites W2010810163 @default.
- W2085338735 cites W2011930216 @default.
- W2085338735 cites W2015897382 @default.
- W2085338735 cites W2021062375 @default.
- W2085338735 cites W2022168818 @default.
- W2085338735 cites W2022646304 @default.
- W2085338735 cites W2025874120 @default.
- W2085338735 cites W2035320640 @default.
- W2085338735 cites W2035745723 @default.
- W2085338735 cites W2040781090 @default.
- W2085338735 cites W2042371265 @default.
- W2085338735 cites W2045227360 @default.
- W2085338735 cites W2045693428 @default.
- W2085338735 cites W2046656665 @default.
- W2085338735 cites W2051987226 @default.
- W2085338735 cites W2052483378 @default.
- W2085338735 cites W2055670148 @default.
- W2085338735 cites W2056211711 @default.
- W2085338735 cites W2056647735 @default.
- W2085338735 cites W2060261810 @default.
- W2085338735 cites W2060896199 @default.
- W2085338735 cites W2066154718 @default.
- W2085338735 cites W2068960261 @default.
- W2085338735 cites W2070174073 @default.
- W2085338735 cites W2074049796 @default.
- W2085338735 cites W2074505948 @default.
- W2085338735 cites W2074729220 @default.
- W2085338735 cites W2082048799 @default.
- W2085338735 cites W2083112584 @default.
- W2085338735 cites W2084458610 @default.
- W2085338735 cites W2084550842 @default.
- W2085338735 cites W2085007727 @default.
- W2085338735 cites W2085789116 @default.
- W2085338735 cites W2090009771 @default.
- W2085338735 cites W2090017399 @default.
- W2085338735 cites W2094444526 @default.
- W2085338735 cites W2096570310 @default.
- W2085338735 cites W2101498579 @default.
- W2085338735 cites W2112123119 @default.
- W2085338735 cites W2112529102 @default.
- W2085338735 cites W2116361632 @default.
- W2085338735 cites W2120177610 @default.
- W2085338735 cites W2122684688 @default.
- W2085338735 cites W2124167019 @default.
- W2085338735 cites W2124876188 @default.
- W2085338735 cites W2127625197 @default.
- W2085338735 cites W2129725688 @default.
- W2085338735 cites W2133634376 @default.
- W2085338735 cites W2134120449 @default.
- W2085338735 cites W2141025633 @default.
- W2085338735 cites W2142416382 @default.
- W2085338735 cites W2145067801 @default.
- W2085338735 cites W2146431258 @default.
- W2085338735 cites W2148006759 @default.
- W2085338735 cites W2152170078 @default.
- W2085338735 cites W2153042602 @default.
- W2085338735 cites W2154241043 @default.
- W2085338735 cites W2157923836 @default.
- W2085338735 cites W2159312946 @default.
- W2085338735 cites W2160516563 @default.
- W2085338735 cites W2168701063 @default.
- W2085338735 cites W36353912 @default.
- W2085338735 cites W4210971654 @default.