FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085340815> ?p ?o ?g. }

• W2085340815 endingPage "710" @default.
• W2085340815 startingPage "701" @default.
• W2085340815 abstract "An increase in synaptosomal Ca2+ triggers neurotransmitter release and volatile anesthetics have been shown to inhibit neurotransmitter release by inhibition of Ca2+ entry.We have examined the effect of isoflurane and halothane on the kinetics of increase and decrease of Ca2+ in rat cerebrocortical synaptosomes ([Ca2+]in). We have also used specific Ca2+ antagonists to examine the role of L-, N-, and P-type Ca2+ channels. Synaptosomal [Ca2+]in was measured spectrofluorometrically using fura-2 as a Ca2+ reporter; Ca2+ transients were initiated by depolarization with 40 mM KCl. We found that <or=to1 minimum alveolar anesthetic concentration halothane and isoflurane decreased peak [Ca2+]in by approximately 40%, that both anesthetics decreased the rate of [Ca2+]in increase and decrease, that specific voltage-dependent calcium channel antagonists had little effect on peak or plateau [Ca2+]in, and that the volatile anesthetics increased the permeability of synaptosomal membranes to Ca2+. These results suggest that the volatile anesthetics, at clinically relevant concentrations, can alter Ca2+ homeostasis in the synapse. Implications: Clinically relevant concentrations of halothane and isoflurane markedly depress K+ -evoked increases in rat cerebrocortical synaptosomal calcium (Ca2+) unrelated to L-, N-, and P-type voltage-dependent calcium channels and increase the Ca2+ permeability of the synaptosomal membrane. These changes in Ca2+ dynamics could have profound effects on Ca2+ signaling in the synapse. (Anesth Analg 1998;87:701-10)" @default.
• W2085340815 created "2016-06-24" @default.
• W2085340815 creator A5012594629 @default.
• W2085340815 creator A5031388726 @default.
• W2085340815 creator A5060839458 @default.
• W2085340815 creator A5086048972 @default.
• W2085340815 date "1998-09-01" @default.
• W2085340815 modified "2023-10-17" @default.
• W2085340815 title "Halothane and Isoflurane Alter Calcium Dynamics in Rat Cerebrocortical Synaptosomes" @default.
• W2085340815 cites W1775749144 @default.
• W2085340815 cites W1980521348 @default.
• W2085340815 cites W1983795558 @default.
• W2085340815 cites W1988782252 @default.
• W2085340815 cites W1988937009 @default.
• W2085340815 cites W1999622205 @default.
• W2085340815 cites W1999772445 @default.
• W2085340815 cites W2007622582 @default.
• W2085340815 cites W2023444285 @default.
• W2085340815 cites W2029544722 @default.
• W2085340815 cites W2032109889 @default.
• W2085340815 cites W2065275383 @default.
• W2085340815 cites W2065330399 @default.
• W2085340815 cites W2069246118 @default.
• W2085340815 cites W2070509477 @default.
• W2085340815 cites W2083264485 @default.
• W2085340815 cites W2085002760 @default.
• W2085340815 cites W2086105359 @default.
• W2085340815 cites W2086662024 @default.
• W2085340815 cites W2105384005 @default.
• W2085340815 cites W2134725139 @default.
• W2085340815 cites W2138437659 @default.
• W2085340815 cites W2141260882 @default.
• W2085340815 cites W2148527746 @default.
• W2085340815 cites W2170336048 @default.
• W2085340815 cites W2176475744 @default.
• W2085340815 cites W4242873845 @default.
• W2085340815 doi "https://doi.org/10.1097/00000539-199809000-00040" @default.
• W2085340815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9728857" @default.
• W2085340815 hasPublicationYear "1998" @default.
• W2085340815 type Work @default.
• W2085340815 sameAs 2085340815 @default.
• W2085340815 citedByCount "9" @default.
• W2085340815 countsByYear W20853408152012 @default.
• W2085340815 countsByYear W20853408152015 @default.
• W2085340815 countsByYear W20853408152022 @default.
• W2085340815 crossrefType "journal-article" @default.
• W2085340815 hasAuthorship W2085340815A5012594629 @default.
• W2085340815 hasAuthorship W2085340815A5031388726 @default.
• W2085340815 hasAuthorship W2085340815A5060839458 @default.
• W2085340815 hasAuthorship W2085340815A5086048972 @default.
• W2085340815 hasBestOaLocation W20853408151 @default.
• W2085340815 hasConcept C12554922 @default.
• W2085340815 hasConcept C126322002 @default.
• W2085340815 hasConcept C134018914 @default.
• W2085340815 hasConcept C181911157 @default.
• W2085340815 hasConcept C18699975 @default.
• W2085340815 hasConcept C2776219046 @default.
• W2085340815 hasConcept C2776359302 @default.
• W2085340815 hasConcept C2776932660 @default.
• W2085340815 hasConcept C2778162923 @default.
• W2085340815 hasConcept C2778921374 @default.
• W2085340815 hasConcept C4141045 @default.
• W2085340815 hasConcept C42219234 @default.
• W2085340815 hasConcept C519063684 @default.
• W2085340815 hasConcept C529278444 @default.
• W2085340815 hasConcept C71924100 @default.
• W2085340815 hasConcept C86803240 @default.
• W2085340815 hasConceptScore W2085340815C12554922 @default.
• W2085340815 hasConceptScore W2085340815C126322002 @default.
• W2085340815 hasConceptScore W2085340815C134018914 @default.
• W2085340815 hasConceptScore W2085340815C181911157 @default.
• W2085340815 hasConceptScore W2085340815C18699975 @default.
• W2085340815 hasConceptScore W2085340815C2776219046 @default.
• W2085340815 hasConceptScore W2085340815C2776359302 @default.
• W2085340815 hasConceptScore W2085340815C2776932660 @default.
• W2085340815 hasConceptScore W2085340815C2778162923 @default.
• W2085340815 hasConceptScore W2085340815C2778921374 @default.
• W2085340815 hasConceptScore W2085340815C4141045 @default.
• W2085340815 hasConceptScore W2085340815C42219234 @default.
• W2085340815 hasConceptScore W2085340815C519063684 @default.
• W2085340815 hasConceptScore W2085340815C529278444 @default.
• W2085340815 hasConceptScore W2085340815C71924100 @default.
• W2085340815 hasConceptScore W2085340815C86803240 @default.
• W2085340815 hasIssue "3" @default.
• W2085340815 hasLocation W20853408151 @default.
• W2085340815 hasLocation W20853408152 @default.
• W2085340815 hasLocation W20853408153 @default.
• W2085340815 hasOpenAccess W2085340815 @default.
• W2085340815 hasPrimaryLocation W20853408151 @default.
• W2085340815 hasRelatedWork W1977062968 @default.
• W2085340815 hasRelatedWork W1999881624 @default.
• W2085340815 hasRelatedWork W2037792996 @default.
• W2085340815 hasRelatedWork W2054466131 @default.
• W2085340815 hasRelatedWork W2103221406 @default.
• W2085340815 hasRelatedWork W2122539177 @default.
• W2085340815 hasRelatedWork W2156629651 @default.
• W2085340815 hasRelatedWork W2461819493 @default.
• W2085340815 hasRelatedWork W4243585289 @default.

• next