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- W2085352254 abstract "Panic attacks are associated with increased autonomic symptoms, suggesting increased beta 2-adrenergic receptor (beta 2AR) function in PD. Tricyclic antidepressants downregulate beta AR function. Previous studies on beta AR function in PD, however, are inconsistent. We recently found increased beta AR coupling and density in neutrophils of symptomatic drug-free PD patients. This study evaluated beta AR coupling to Gs protein in 28 controls, 25 drug-free PD patients and 8 PD imipramine-treated patients. PD patients had significantly higher coupling and receptor density, particularly in the high-conformational state. Differences were more pronounced in patients with less depressive symptomatology. Treatment with imipramine was associated with decreased beta AR coupling and density in the high-conformational state. Several beta AR binding parameters were related to severity of anxiety symptoms and treatment outcome. Antidepressants downregulate beta AR density and induce uncoupling from Gs protein in PD. Future studies may investigate beta AR coupling in relationship to treatment outcome and the role of beta AR kinase in PD." @default.
- W2085352254 created "2016-06-24" @default.
- W2085352254 creator A5013246959 @default.
- W2085352254 creator A5032794196 @default.
- W2085352254 creator A5034124712 @default.
- W2085352254 creator A5044520110 @default.
- W2085352254 creator A5056181252 @default.
- W2085352254 creator A5056859584 @default.
- W2085352254 creator A5065474705 @default.
- W2085352254 date "1999-07-08" @default.
- W2085352254 modified "2023-09-27" @default.
- W2085352254 title "Adrenergic receptor function in panic disorder II. Neutrophil β2 receptors: Gs protein coupling, effects of imipramine treatment and relationship to treatment outcome" @default.
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