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• W2085352255 abstract "Prior analyses of the proteome of the protozoan parasite Leishmania have underrepresented basic proteins. Here, we applied protein fractionation by isoelectric point (pI) using free-flow electrophoresis (FFE) to study stage-specific expression of basic proteins in this pathogen. Overall, we resolved 2469 protein spots in both the flagellated promastigote and the nonmotile amastigote forms in the basic range by two-dimensional gel electrophoresis (2-DE). Highly basic proteins were enriched by FFE fractionation, allowing many to be identified and characterized for the first time by proteomics analysis. Among proteins upregulated in the promastigote stage, we found glycolytic enzymes and flagellar proteins. Proteins upregulated in the amastigote stage included enzymes involved in gluconeogenesis and fatty acid beta-oxidation. In both life stages, many proteins were found in multiple spots or as proteolytic fragments, suggesting that extensive post-translational modification and processing occur. Interestingly, evidence was obtained suggesting that some of these processes may be stage-specific." @default.
• W2085352255 created "2016-06-24" @default.
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• W2085352255 date "2010-07-21" @default.
• W2085352255 modified "2023-09-27" @default.
• W2085352255 title "Analysis of Stage-Specific Expression of Basic Proteins in <i>Leishmania infantum</i>" @default.
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• W2085352255 doi "https://doi.org/10.1021/pr100048m" @default.
• W2085352255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20583757" @default.
• W2085352255 hasPublicationYear "2010" @default.
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