FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085355313> ?p ?o ?g. }

• W2085355313 endingPage "282" @default.
• W2085355313 startingPage "277" @default.
• W2085355313 abstract "The habit of betel nut chewing impinges on the daily lives of approximately 200 million people. Betel quid chewers have a higher prevalence of periodontal diseases than non-chewers. This study examined the pathobiological effects of arecoline, a major component of the betel nut alkaloids, on human periodontal ligament fibroblasts (PDLF) in vitro.Cell viability, proliferation, protein synthesis, and cellular thiol levels were used to investigate the effects of human PDLF exposed to arecoline levels of 0 to 200 microg/ml. In addition, nicotine was added to test how it modulated the effects of arecoline.Arecoline significantly inhibited cell proliferation in a dose-dependent manner. At concentrations of 10 and 30 microg/ml, arecoline suppressed the growth of PDLF by 20% and 50% (p < 0.05), respectively. Arecoline also decreased protein synthesis in a dose-dependent manner during a 24-h culture period. A 100 microg/ ml concentration level of arecoline significantly inhibited protein synthesis to only 50% of that in the untreated control (p < 0.05). Moreover, arecoline significantly depleted intracellular thiols in a dose-dependent manner. At concentrations of 25 microg/ml and 100 microg/ml, arecoline depleted about 18% and 56% of thiols (p < 0.05), respectively. This suggests that arecoline itself might augment the destruction of periodontium associated with betel nut use. Furthermore, the addition of nicotine acted with a synergistic effect on the arecoline-induced cytotoxicity. At a concentration of 60 microg/ml, arecoline suppressed the growth of PDLF by about 33% and 5 mM nicotine enhanced the arecoline-induced cytotoxic response to cause about 66% cell death.During thiol depletion, arecoline may render human PDLF more vulnerable to reactive agents within cigarettes. Taken together, people who combine habits of betel nut chewing with cigarette smoking could be more susceptible to periodontium damage than betel nut chewing alone." @default.
• W2085355313 created "2016-06-24" @default.
• W2085355313 creator A5051943635 @default.
• W2085355313 creator A5054035698 @default.
• W2085355313 creator A5060018552 @default.
• W2085355313 creator A5081898709 @default.
• W2085355313 date "2001-03-01" @default.
• W2085355313 modified "2023-10-18" @default.
• W2085355313 title "Adverse effects of arecoline and nicotine on human periodontal ligament fibroblasts in vitro" @default.
• W2085355313 cites W1511013913 @default.
• W2085355313 cites W1847374467 @default.
• W2085355313 cites W1941759272 @default.
• W2085355313 cites W1964789930 @default.
• W2085355313 cites W1970749702 @default.
• W2085355313 cites W1977090090 @default.
• W2085355313 cites W1978420997 @default.
• W2085355313 cites W1979858380 @default.
• W2085355313 cites W1982646240 @default.
• W2085355313 cites W1984516919 @default.
• W2085355313 cites W1992974353 @default.
• W2085355313 cites W1999377058 @default.
• W2085355313 cites W2012660829 @default.
• W2085355313 cites W2013133334 @default.
• W2085355313 cites W2019754071 @default.
• W2085355313 cites W2031156135 @default.
• W2085355313 cites W2032589830 @default.
• W2085355313 cites W2049172251 @default.
• W2085355313 cites W2066266855 @default.
• W2085355313 cites W2069911417 @default.
• W2085355313 cites W2077614730 @default.
• W2085355313 cites W2077710254 @default.
• W2085355313 cites W2078790815 @default.
• W2085355313 cites W2083226954 @default.
• W2085355313 cites W2104239271 @default.
• W2085355313 cites W2110506459 @default.
• W2085355313 cites W2114918609 @default.
• W2085355313 cites W2115628627 @default.
• W2085355313 cites W2123848566 @default.
• W2085355313 cites W2133936351 @default.
• W2085355313 cites W2156376285 @default.
• W2085355313 cites W2388073033 @default.
• W2085355313 doi "https://doi.org/10.1034/j.1600-051x.2001.028003277.x" @default.
• W2085355313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11284543" @default.
• W2085355313 hasPublicationYear "2001" @default.
• W2085355313 type Work @default.
• W2085355313 sameAs 2085355313 @default.
• W2085355313 citedByCount "60" @default.
• W2085355313 countsByYear W20853553132012 @default.
• W2085355313 countsByYear W20853553132014 @default.
• W2085355313 countsByYear W20853553132015 @default.
• W2085355313 countsByYear W20853553132016 @default.
• W2085355313 countsByYear W20853553132018 @default.
• W2085355313 countsByYear W20853553132019 @default.
• W2085355313 countsByYear W20853553132020 @default.
• W2085355313 countsByYear W20853553132021 @default.
• W2085355313 countsByYear W20853553132022 @default.
• W2085355313 countsByYear W20853553132023 @default.
• W2085355313 crossrefType "journal-article" @default.
• W2085355313 hasAuthorship W2085355313A5051943635 @default.
• W2085355313 hasAuthorship W2085355313A5054035698 @default.
• W2085355313 hasAuthorship W2085355313A5060018552 @default.
• W2085355313 hasAuthorship W2085355313A5081898709 @default.
• W2085355313 hasConcept C126322002 @default.
• W2085355313 hasConcept C127413603 @default.
• W2085355313 hasConcept C170493617 @default.
• W2085355313 hasConcept C185592680 @default.
• W2085355313 hasConcept C199343813 @default.
• W2085355313 hasConcept C202751555 @default.
• W2085355313 hasConcept C206391251 @default.
• W2085355313 hasConcept C2777417228 @default.
• W2085355313 hasConcept C2779547902 @default.
• W2085355313 hasConcept C2781277053 @default.
• W2085355313 hasConcept C33789571 @default.
• W2085355313 hasConcept C41868710 @default.
• W2085355313 hasConcept C55493867 @default.
• W2085355313 hasConcept C66938386 @default.
• W2085355313 hasConcept C71924100 @default.
• W2085355313 hasConcept C98274493 @default.
• W2085355313 hasConceptScore W2085355313C126322002 @default.
• W2085355313 hasConceptScore W2085355313C127413603 @default.
• W2085355313 hasConceptScore W2085355313C170493617 @default.
• W2085355313 hasConceptScore W2085355313C185592680 @default.
• W2085355313 hasConceptScore W2085355313C199343813 @default.
• W2085355313 hasConceptScore W2085355313C202751555 @default.
• W2085355313 hasConceptScore W2085355313C206391251 @default.
• W2085355313 hasConceptScore W2085355313C2777417228 @default.
• W2085355313 hasConceptScore W2085355313C2779547902 @default.
• W2085355313 hasConceptScore W2085355313C2781277053 @default.
• W2085355313 hasConceptScore W2085355313C33789571 @default.
• W2085355313 hasConceptScore W2085355313C41868710 @default.
• W2085355313 hasConceptScore W2085355313C55493867 @default.
• W2085355313 hasConceptScore W2085355313C66938386 @default.
• W2085355313 hasConceptScore W2085355313C71924100 @default.
• W2085355313 hasConceptScore W2085355313C98274493 @default.
• W2085355313 hasIssue "3" @default.
• W2085355313 hasLocation W20853553131 @default.
• W2085355313 hasLocation W20853553132 @default.
• W2085355313 hasOpenAccess W2085355313 @default.

• next