FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085355921> ?p ?o ?g. }

• W2085355921 endingPage "812" @default.
• W2085355921 startingPage "805" @default.
• W2085355921 abstract "The vascular endothelium may develop a proinflammatory profile with aging, but evidence is limited in humans. Expression of inflammatory proteins was determined in vascular endothelial cells (EC) obtained from peripheral veins of 24 young (23 ± 1 years, mean ± SE) and 36 older (63 ± 1) healthy men and women using quantitative immunofluorescence. The older subjects had lower vascular endothelium-dependent dilation (forearm blood flow responses to acetylcholine, p < 0.05), and higher plasma concentrations of C-reactive protein, interleukin-6 (IL-6), and oxidized low-density lipoprotein (all p < 0.05), but not tumor necrosis factor-α (TNF-α). Total (O: 0.52 ± 0.04 vs. Y: 0.33 ± 0.05 NFκB/HUVEC intensity, p < 0.05) and nuclear (O: 0.59 ± 0.04 vs. Y: 0.41 ± 0.04) expression of nuclear factor κ B p65 (NFκB), a proinflammatory gene transcription factor, was greater in EC from the older subjects (p < 0.05). EC expression of the inhibitor (of nuclear translocation) of NFκB (IκBα) was lower in the older subjects (O: 0.16 ± 0.02 vs. Y: 0.24 ± 0.03, p < 0.05), whereas IκB kinase (IκK) was not different. EC expression of the proinflammatory proteins IL-6 (O: 0.42 ± 0.06 vs. Y: 0.29 ± 0.03, p < 0.05), TNF-α (O: 0.52 ± 0.06 vs. Y: 0.33 ± 0.05, p < 0.05) and monocyte chemoattractant protein 1 (MCP-1) (O: 0.59 ± 0.06 vs. Y: 0.38 ± 0.02, p < 0.05) was greater in the older subjects, whereas cyclooxygenase 2 and the receptor for advanced glycation end-products did not differ. These findings indicate that impaired function with aging in healthy adults is associated with the development of a proinflammatory phenotype in the vascular endothelium that could be caused in part by reduced IκB-mediated inhibition of NFκB." @default.
• W2085355921 created "2016-06-24" @default.
• W2085355921 creator A5066649727 @default.
• W2085355921 creator A5075109445 @default.
• W2085355921 creator A5085594267 @default.
• W2085355921 creator A5087335835 @default.
• W2085355921 creator A5091792035 @default.
• W2085355921 date "2008-12-01" @default.
• W2085355921 modified "2023-09-27" @default.
• W2085355921 title "Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans" @default.
• W2085355921 cites W119636436 @default.
• W2085355921 cites W1480466711 @default.
• W2085355921 cites W1538110087 @default.
• W2085355921 cites W1595822167 @default.
• W2085355921 cites W1975828200 @default.
• W2085355921 cites W1986439538 @default.
• W2085355921 cites W2012092765 @default.
• W2085355921 cites W2028159706 @default.
• W2085355921 cites W2045601200 @default.
• W2085355921 cites W2054893928 @default.
• W2085355921 cites W2056816257 @default.
• W2085355921 cites W2063058274 @default.
• W2085355921 cites W2069200731 @default.
• W2085355921 cites W2076633296 @default.
• W2085355921 cites W2088639163 @default.
• W2085355921 cites W2095847921 @default.
• W2085355921 cites W2097750015 @default.
• W2085355921 cites W2098113072 @default.
• W2085355921 cites W2105767743 @default.
• W2085355921 cites W2110619084 @default.
• W2085355921 cites W2113082835 @default.
• W2085355921 cites W2118874116 @default.
• W2085355921 cites W2120058838 @default.
• W2085355921 cites W2121622875 @default.
• W2085355921 cites W2125419594 @default.
• W2085355921 cites W2128126753 @default.
• W2085355921 cites W2130666962 @default.
• W2085355921 cites W2133123327 @default.
• W2085355921 cites W2135312900 @default.
• W2085355921 cites W2136772666 @default.
• W2085355921 cites W2139473917 @default.
• W2085355921 cites W2139500689 @default.
• W2085355921 cites W2142060886 @default.
• W2085355921 cites W2145200932 @default.
• W2085355921 cites W2153409761 @default.
• W2085355921 cites W2159087408 @default.
• W2085355921 cites W2171284332 @default.
• W2085355921 cites W2191264255 @default.
• W2085355921 cites W2615584519 @default.
• W2085355921 cites W3015544325 @default.
• W2085355921 doi "https://doi.org/10.1111/j.1474-9726.2008.00438.x" @default.
• W2085355921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3032405" @default.
• W2085355921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18782346" @default.
• W2085355921 hasPublicationYear "2008" @default.
• W2085355921 type Work @default.
• W2085355921 sameAs 2085355921 @default.
• W2085355921 citedByCount "220" @default.
• W2085355921 countsByYear W20853559212012 @default.
• W2085355921 countsByYear W20853559212013 @default.
• W2085355921 countsByYear W20853559212014 @default.
• W2085355921 countsByYear W20853559212015 @default.
• W2085355921 countsByYear W20853559212016 @default.
• W2085355921 countsByYear W20853559212017 @default.
• W2085355921 countsByYear W20853559212018 @default.
• W2085355921 countsByYear W20853559212019 @default.
• W2085355921 countsByYear W20853559212020 @default.
• W2085355921 countsByYear W20853559212021 @default.
• W2085355921 countsByYear W20853559212022 @default.
• W2085355921 countsByYear W20853559212023 @default.
• W2085355921 crossrefType "journal-article" @default.
• W2085355921 hasAuthorship W2085355921A5066649727 @default.
• W2085355921 hasAuthorship W2085355921A5075109445 @default.
• W2085355921 hasAuthorship W2085355921A5085594267 @default.
• W2085355921 hasAuthorship W2085355921A5087335835 @default.
• W2085355921 hasAuthorship W2085355921A5091792035 @default.
• W2085355921 hasBestOaLocation W20853559211 @default.
• W2085355921 hasConcept C11988809 @default.
• W2085355921 hasConcept C126322002 @default.
• W2085355921 hasConcept C134018914 @default.
• W2085355921 hasConcept C164027704 @default.
• W2085355921 hasConcept C167734588 @default.
• W2085355921 hasConcept C17991360 @default.
• W2085355921 hasConcept C2776246508 @default.
• W2085355921 hasConcept C2776914184 @default.
• W2085355921 hasConcept C2776992346 @default.
• W2085355921 hasConcept C2777025900 @default.
• W2085355921 hasConcept C2780972559 @default.
• W2085355921 hasConcept C2781184567 @default.
• W2085355921 hasConcept C71924100 @default.
• W2085355921 hasConcept C86803240 @default.
• W2085355921 hasConceptScore W2085355921C11988809 @default.
• W2085355921 hasConceptScore W2085355921C126322002 @default.
• W2085355921 hasConceptScore W2085355921C134018914 @default.
• W2085355921 hasConceptScore W2085355921C164027704 @default.
• W2085355921 hasConceptScore W2085355921C167734588 @default.
• W2085355921 hasConceptScore W2085355921C17991360 @default.
• W2085355921 hasConceptScore W2085355921C2776246508 @default.
• W2085355921 hasConceptScore W2085355921C2776914184 @default.

• next