FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085363437> ?p ?o ?g. }

• W2085363437 endingPage "122" @default.
• W2085363437 startingPage "118" @default.
• W2085363437 abstract "Astrocytes are thought to play a role in the maintenance of homeostasis and the provision of metabolic substrates for neurons as well as the coupling of cerebral blood flow to neuronal activity. Accordingly, astrocytic death due to various types of injury can critically influence neuronal survival. The exact pathway of cell death after brain ischemia is under debate. In the present study, we used astrocytes from rat primary culture treated with persistent oxygen-glucose-deprivation (OGD) as a model of ischemia to examine the pathway of cell death and the relevant mechanisms. We observed changes in the cellular morphology, the energy metabolism of astrocytes, and the percentage of apoptosis or oncosis of the astrocytes induced by OGD. Electron microscopy revealed the co-existence of ultrastructural features in both apoptosis and oncosis in individual cells. The cellular ATP content was gradually decreased and the percentages of apoptotic and oncotic cells were increased during OGD. After 4h of OGD, ATP depletion to less than 35% of the control was observed, and oncosis became the primary pathway for astrocytic death. Increased plasma membrane permeability due to oncosis was associated with increased calpain-mediated degradation of several cytoskeletal proteins, including paxillin, vinculin, vimentin and GFAP. Pre-treatment with the calpain inhibitor 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD150606) could delay the OGD-induced astrocytic oncosis. These results suggest that there is a narrow range of ATP that determines astrocytic oncotic death induced by persistent OGD and that calpain-mediated hydrolysis of the cytoskeletal-associated proteins may contribute to astrocytes oncosis." @default.
• W2085363437 created "2016-06-24" @default.
• W2085363437 creator A5030906930 @default.
• W2085363437 creator A5042973046 @default.
• W2085363437 creator A5044006431 @default.
• W2085363437 creator A5046633371 @default.
• W2085363437 creator A5085350603 @default.
• W2085363437 creator A5090429810 @default.
• W2085363437 date "2010-07-01" @default.
• W2085363437 modified "2023-09-30" @default.
• W2085363437 title "Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosis" @default.
• W2085363437 cites W1491399076 @default.
• W2085363437 cites W1504164986 @default.
• W2085363437 cites W1852518919 @default.
• W2085363437 cites W1961967618 @default.
• W2085363437 cites W1964113011 @default.
• W2085363437 cites W1972059711 @default.
• W2085363437 cites W1980336239 @default.
• W2085363437 cites W1986203478 @default.
• W2085363437 cites W2003819256 @default.
• W2085363437 cites W2021400734 @default.
• W2085363437 cites W2023407559 @default.
• W2085363437 cites W2038897484 @default.
• W2085363437 cites W2046903610 @default.
• W2085363437 cites W2051450147 @default.
• W2085363437 cites W2057210920 @default.
• W2085363437 cites W2060204808 @default.
• W2085363437 cites W2060556528 @default.
• W2085363437 cites W2062428280 @default.
• W2085363437 cites W2066554451 @default.
• W2085363437 cites W2068630823 @default.
• W2085363437 cites W2070588153 @default.
• W2085363437 cites W2080015189 @default.
• W2085363437 cites W2083771230 @default.
• W2085363437 cites W2088766816 @default.
• W2085363437 cites W2132889264 @default.
• W2085363437 cites W2135325091 @default.
• W2085363437 cites W2142405774 @default.
• W2085363437 cites W2153916795 @default.
• W2085363437 cites W2263706743 @default.
• W2085363437 doi "https://doi.org/10.1016/j.neulet.2010.05.040" @default.
• W2085363437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20493926" @default.
• W2085363437 hasPublicationYear "2010" @default.
• W2085363437 type Work @default.
• W2085363437 sameAs 2085363437 @default.
• W2085363437 citedByCount "27" @default.
• W2085363437 countsByYear W20853634372012 @default.
• W2085363437 countsByYear W20853634372013 @default.
• W2085363437 countsByYear W20853634372014 @default.
• W2085363437 countsByYear W20853634372015 @default.
• W2085363437 countsByYear W20853634372016 @default.
• W2085363437 countsByYear W20853634372018 @default.
• W2085363437 countsByYear W20853634372019 @default.
• W2085363437 countsByYear W20853634372020 @default.
• W2085363437 countsByYear W20853634372021 @default.
• W2085363437 countsByYear W20853634372022 @default.
• W2085363437 countsByYear W20853634372023 @default.
• W2085363437 crossrefType "journal-article" @default.
• W2085363437 hasAuthorship W2085363437A5030906930 @default.
• W2085363437 hasAuthorship W2085363437A5042973046 @default.
• W2085363437 hasAuthorship W2085363437A5044006431 @default.
• W2085363437 hasAuthorship W2085363437A5046633371 @default.
• W2085363437 hasAuthorship W2085363437A5085350603 @default.
• W2085363437 hasAuthorship W2085363437A5090429810 @default.
• W2085363437 hasConcept C142669718 @default.
• W2085363437 hasConcept C1491633281 @default.
• W2085363437 hasConcept C169760540 @default.
• W2085363437 hasConcept C181199279 @default.
• W2085363437 hasConcept C190283241 @default.
• W2085363437 hasConcept C2777542381 @default.
• W2085363437 hasConcept C31573885 @default.
• W2085363437 hasConcept C529278444 @default.
• W2085363437 hasConcept C55493867 @default.
• W2085363437 hasConcept C56928146 @default.
• W2085363437 hasConcept C86803240 @default.
• W2085363437 hasConcept C95444343 @default.
• W2085363437 hasConceptScore W2085363437C142669718 @default.
• W2085363437 hasConceptScore W2085363437C1491633281 @default.
• W2085363437 hasConceptScore W2085363437C169760540 @default.
• W2085363437 hasConceptScore W2085363437C181199279 @default.
• W2085363437 hasConceptScore W2085363437C190283241 @default.
• W2085363437 hasConceptScore W2085363437C2777542381 @default.
• W2085363437 hasConceptScore W2085363437C31573885 @default.
• W2085363437 hasConceptScore W2085363437C529278444 @default.
• W2085363437 hasConceptScore W2085363437C55493867 @default.
• W2085363437 hasConceptScore W2085363437C56928146 @default.
• W2085363437 hasConceptScore W2085363437C86803240 @default.
• W2085363437 hasConceptScore W2085363437C95444343 @default.
• W2085363437 hasIssue "2" @default.
• W2085363437 hasLocation W20853634371 @default.
• W2085363437 hasLocation W20853634372 @default.
• W2085363437 hasOpenAccess W2085363437 @default.
• W2085363437 hasPrimaryLocation W20853634371 @default.
• W2085363437 hasRelatedWork W1493497188 @default.
• W2085363437 hasRelatedWork W1980132339 @default.
• W2085363437 hasRelatedWork W1987695408 @default.
• W2085363437 hasRelatedWork W2004906000 @default.
• W2085363437 hasRelatedWork W2009311291 @default.

• next