FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085363493> ?p ?o ?g. }

• W2085363493 endingPage "617" @default.
• W2085363493 startingPage "609" @default.
• W2085363493 abstract "A form of impulsivity, the tendency to choose immediate over delayed rewards (delay-discounting) has been associated with a single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene (COMTval¹⁵⁸met; rs4680). However, the existing data regarding the nature of this association are in conflict. We have previously reported that adults homozygous for valine (val) at the COMTval¹⁵⁸met SNP demonstrate greater delay-discounting than do methionine (met) allele carriers (Boettiger et al., J Neurosci 27:14383-14391, 2007). In contrast, a recent study of adolescent males found that those with the met/met genotype demonstrate greater delay-discounting than do val-allele carriers (Paloyelis et al., Neuropsychopharmacology 35:2414-2426, 2010). Based on reported age-related changes in frontal dopamine function and COMT expression, we hypothesized that the association of COMT genotype with delay-discounting behavior is modulated by age from late adolescence to young adulthood.To test this hypothesis, we genotyped late adolescents (18-21 years; n = 72) and adults (22-40 years; n = 70) for the COMTval¹⁵⁸met polymorphism, measured their delay-discounting behavior, and tested for an interaction between age group and COMT genotype.This cross-sectional study found that age modulates COMTval¹⁵⁸met genotype effects on delay-discounting behavior. Among met-carriers, delay-discounting was negatively correlated with age from late adolescence to adulthood, while among val/val individuals delay-discounting was positively correlated with age across this range.These results confirm our previous finding of enhanced delay-discounting among val/val adults relative to met-allele carriers, and help reconcile existing literature. We propose a single U-shaped model of the relationship between frontal DA levels and impulsive choice that accounts for both adolescent and adult data." @default.
• W2085363493 created "2016-06-24" @default.
• W2085363493 creator A5035573627 @default.
• W2085363493 creator A5049669065 @default.
• W2085363493 date "2012-02-18" @default.
• W2085363493 modified "2023-10-07" @default.
• W2085363493 title "Age modulates the effect of COMT genotype on delay discounting behavior" @default.
• W2085363493 cites W1520514652 @default.
• W2085363493 cites W1527753734 @default.
• W2085363493 cites W1599573627 @default.
• W2085363493 cites W1659384861 @default.
• W2085363493 cites W1971976749 @default.
• W2085363493 cites W1977764783 @default.
• W2085363493 cites W1978443369 @default.
• W2085363493 cites W1983543998 @default.
• W2085363493 cites W1986059489 @default.
• W2085363493 cites W1994077204 @default.
• W2085363493 cites W1994298252 @default.
• W2085363493 cites W1997343027 @default.
• W2085363493 cites W2006619603 @default.
• W2085363493 cites W2008679805 @default.
• W2085363493 cites W2014986939 @default.
• W2085363493 cites W2024565531 @default.
• W2085363493 cites W2026271277 @default.
• W2085363493 cites W2031228519 @default.
• W2085363493 cites W2031552645 @default.
• W2085363493 cites W2032471892 @default.
• W2085363493 cites W2032866243 @default.
• W2085363493 cites W2043293226 @default.
• W2085363493 cites W2046479615 @default.
• W2085363493 cites W2054856852 @default.
• W2085363493 cites W2057198064 @default.
• W2085363493 cites W2059057473 @default.
• W2085363493 cites W2062990061 @default.
• W2085363493 cites W2063404606 @default.
• W2085363493 cites W2065313845 @default.
• W2085363493 cites W2067218568 @default.
• W2085363493 cites W2072542232 @default.
• W2085363493 cites W2073363296 @default.
• W2085363493 cites W2082078342 @default.
• W2085363493 cites W2082117755 @default.
• W2085363493 cites W2086982304 @default.
• W2085363493 cites W2093327286 @default.
• W2085363493 cites W2095621691 @default.
• W2085363493 cites W2100040984 @default.
• W2085363493 cites W2105837661 @default.
• W2085363493 cites W2109691697 @default.
• W2085363493 cites W2112650295 @default.
• W2085363493 cites W2113324723 @default.
• W2085363493 cites W2119095023 @default.
• W2085363493 cites W2119410682 @default.
• W2085363493 cites W2120731293 @default.
• W2085363493 cites W2120970072 @default.
• W2085363493 cites W2125080419 @default.
• W2085363493 cites W2131510354 @default.
• W2085363493 cites W2132377514 @default.
• W2085363493 cites W2133169656 @default.
• W2085363493 cites W2139789613 @default.
• W2085363493 cites W2140142910 @default.
• W2085363493 cites W2145107370 @default.
• W2085363493 cites W2146473511 @default.
• W2085363493 cites W2151204406 @default.
• W2085363493 cites W2153614880 @default.
• W2085363493 cites W2154089679 @default.
• W2085363493 cites W2163840979 @default.
• W2085363493 cites W2166144428 @default.
• W2085363493 cites W2168203121 @default.
• W2085363493 cites W2300224149 @default.
• W2085363493 cites W4210564372 @default.
• W2085363493 cites W4213003651 @default.
• W2085363493 doi "https://doi.org/10.1007/s00213-012-2653-9" @default.
• W2085363493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3401276" @default.
• W2085363493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22349272" @default.
• W2085363493 hasPublicationYear "2012" @default.
• W2085363493 type Work @default.
• W2085363493 sameAs 2085363493 @default.
• W2085363493 citedByCount "51" @default.
• W2085363493 countsByYear W20853634932013 @default.
• W2085363493 countsByYear W20853634932014 @default.
• W2085363493 countsByYear W20853634932015 @default.
• W2085363493 countsByYear W20853634932016 @default.
• W2085363493 countsByYear W20853634932017 @default.
• W2085363493 countsByYear W20853634932018 @default.
• W2085363493 countsByYear W20853634932019 @default.
• W2085363493 countsByYear W20853634932020 @default.
• W2085363493 countsByYear W20853634932021 @default.
• W2085363493 countsByYear W20853634932022 @default.
• W2085363493 countsByYear W20853634932023 @default.
• W2085363493 crossrefType "journal-article" @default.
• W2085363493 hasAuthorship W2085363493A5035573627 @default.
• W2085363493 hasAuthorship W2085363493A5049669065 @default.
• W2085363493 hasBestOaLocation W20853634932 @default.
• W2085363493 hasConcept C104317684 @default.
• W2085363493 hasConcept C126322002 @default.
• W2085363493 hasConcept C135763542 @default.
• W2085363493 hasConcept C138496976 @default.
• W2085363493 hasConcept C153209595 @default.
• W2085363493 hasConcept C15744967 @default.

• next