Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085366399> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2085366399 endingPage "1047" @default.
- W2085366399 startingPage "1045" @default.
- W2085366399 abstract "This study was undertaken to evaluate an assay to assess the risk for drug-induced immediate hypersensitivity reactions. Groups of five to 10 guinea-pigs were given six ip injections of the test compound on days 1, 3, 5, 8, 10 and 12. Aluminium hydroxide was also given in the first injection. At day 33, the animals were given an iv injection of the test compound and the response was recorded by grading the severity of clinical symptoms. Cutaneous passive anaphylaxis was also evaluated in six naive guinea pigs using Evans blue and sera collected from treated animals on day 26. A panel of six positive model compounds (ovalbumin, aprotinin, chymopapain, tetracosactide, cyanocobalamin and procaine), and the negative compound Ribomunyl were tested. Positive systemic and/or cutaneous anaphylactic responses were observed with ovalbumin, aprotinin, chymopapain and tetracosactide whereas no responses were noted with cyanocobalamin, procaine and Ribomunyl. Our results suggest that this protocol can help differentiate positive model compounds (known to induce reactions in man) from negative model compounds, provided that their molecular weight is large enough, but that it is not applicable to substances of low molecular weight." @default.
- W2085366399 created "2016-06-24" @default.
- W2085366399 creator A5020486190 @default.
- W2085366399 creator A5034958003 @default.
- W2085366399 creator A5044273854 @default.
- W2085366399 creator A5086246621 @default.
- W2085366399 date "1994-10-01" @default.
- W2085366399 modified "2023-10-03" @default.
- W2085366399 title "Prediction of drug-induced immediate hypersensitivity in guinea pigs" @default.
- W2085366399 cites W1974459169 @default.
- W2085366399 cites W1987386803 @default.
- W2085366399 cites W2057972096 @default.
- W2085366399 cites W2060641076 @default.
- W2085366399 cites W2066637306 @default.
- W2085366399 cites W2112612330 @default.
- W2085366399 doi "https://doi.org/10.1016/0887-2333(94)90242-9" @default.
- W2085366399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20693069" @default.
- W2085366399 hasPublicationYear "1994" @default.
- W2085366399 type Work @default.
- W2085366399 sameAs 2085366399 @default.
- W2085366399 citedByCount "12" @default.
- W2085366399 countsByYear W20853663992012 @default.
- W2085366399 countsByYear W20853663992016 @default.
- W2085366399 countsByYear W20853663992022 @default.
- W2085366399 crossrefType "journal-article" @default.
- W2085366399 hasAuthorship W2085366399A5020486190 @default.
- W2085366399 hasAuthorship W2085366399A5034958003 @default.
- W2085366399 hasAuthorship W2085366399A5044273854 @default.
- W2085366399 hasAuthorship W2085366399A5086246621 @default.
- W2085366399 hasConcept C126322002 @default.
- W2085366399 hasConcept C147483822 @default.
- W2085366399 hasConcept C203014093 @default.
- W2085366399 hasConcept C207480886 @default.
- W2085366399 hasConcept C2775933838 @default.
- W2085366399 hasConcept C2776946954 @default.
- W2085366399 hasConcept C2777649898 @default.
- W2085366399 hasConcept C2778815084 @default.
- W2085366399 hasConcept C2779060952 @default.
- W2085366399 hasConcept C2780035454 @default.
- W2085366399 hasConcept C2780799893 @default.
- W2085366399 hasConcept C42219234 @default.
- W2085366399 hasConcept C71924100 @default.
- W2085366399 hasConcept C98274493 @default.
- W2085366399 hasConceptScore W2085366399C126322002 @default.
- W2085366399 hasConceptScore W2085366399C147483822 @default.
- W2085366399 hasConceptScore W2085366399C203014093 @default.
- W2085366399 hasConceptScore W2085366399C207480886 @default.
- W2085366399 hasConceptScore W2085366399C2775933838 @default.
- W2085366399 hasConceptScore W2085366399C2776946954 @default.
- W2085366399 hasConceptScore W2085366399C2777649898 @default.
- W2085366399 hasConceptScore W2085366399C2778815084 @default.
- W2085366399 hasConceptScore W2085366399C2779060952 @default.
- W2085366399 hasConceptScore W2085366399C2780035454 @default.
- W2085366399 hasConceptScore W2085366399C2780799893 @default.
- W2085366399 hasConceptScore W2085366399C42219234 @default.
- W2085366399 hasConceptScore W2085366399C71924100 @default.
- W2085366399 hasConceptScore W2085366399C98274493 @default.
- W2085366399 hasIssue "5" @default.
- W2085366399 hasLocation W20853663991 @default.
- W2085366399 hasLocation W20853663992 @default.
- W2085366399 hasOpenAccess W2085366399 @default.
- W2085366399 hasPrimaryLocation W20853663991 @default.
- W2085366399 hasRelatedWork W131997416 @default.
- W2085366399 hasRelatedWork W1562556363 @default.
- W2085366399 hasRelatedWork W1631235711 @default.
- W2085366399 hasRelatedWork W2073358883 @default.
- W2085366399 hasRelatedWork W2085366399 @default.
- W2085366399 hasRelatedWork W2970951906 @default.
- W2085366399 hasRelatedWork W3198042813 @default.
- W2085366399 hasRelatedWork W3201567132 @default.
- W2085366399 hasRelatedWork W4231521050 @default.
- W2085366399 hasRelatedWork W4243646261 @default.
- W2085366399 hasVolume "8" @default.
- W2085366399 isParatext "false" @default.
- W2085366399 isRetracted "false" @default.
- W2085366399 magId "2085366399" @default.
- W2085366399 workType "article" @default.