Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085367013> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2085367013 endingPage "22" @default.
- W2085367013 startingPage "15" @default.
- W2085367013 abstract "Endothelium-dependent relaxations cannot be fully explained by the release of either NO or/and prostacyclin. Another unidentified substance(s) which hyperpolarizes the underlying vascular smooth muscle cells may contribute to endothelium-dependent relaxations, especially in small arteries. It has been termed endothelium-derived hyperpolarizing factor (EDHF). In blood vessels from various species including humans, endothelium-dependent relaxations are partially or totally resistant to inhibitors of NO synthase and cyclooxygenase and are observed without an increase in the intracellular level of cyclic nucleotides in the vascular smooth muscle cells. In some species (canine, porcine and human) nitrovasodilators do not cause hyperpolarization while in other (rat, guinea-pig, rabbit), they evoke glibenclamide-sensitive hyperpolarization, suggesting the involvement of ATP-dependent potassium channels. In contrast, hyperpolarizations caused by EDHF are insensitive to glibenclamide but are inhibited by apamin or the combination of charybdotoxin plus apamin, indicating that NO and EDHF interact with two different targets. The existence of EDHF as a diffusable substance has been demonstrated under bioassay conditions whereby the source of EDHF was either native vascular segments or cultured endothelial cells. The identification of EDHF may allow a better understanding of its physiological and pathophysiological role(s)." @default.
- W2085367013 created "2016-06-24" @default.
- W2085367013 creator A5027121686 @default.
- W2085367013 creator A5033869623 @default.
- W2085367013 date "1999-01-01" @default.
- W2085367013 modified "2023-10-18" @default.
- W2085367013 title "The Alternative: EDHF" @default.
- W2085367013 doi "https://doi.org/10.1006/jmcc.1998.0840" @default.
- W2085367013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10072712" @default.
- W2085367013 hasPublicationYear "1999" @default.
- W2085367013 type Work @default.
- W2085367013 sameAs 2085367013 @default.
- W2085367013 citedByCount "121" @default.
- W2085367013 countsByYear W20853670132013 @default.
- W2085367013 countsByYear W20853670132014 @default.
- W2085367013 countsByYear W20853670132015 @default.
- W2085367013 countsByYear W20853670132016 @default.
- W2085367013 countsByYear W20853670132017 @default.
- W2085367013 countsByYear W20853670132018 @default.
- W2085367013 countsByYear W20853670132019 @default.
- W2085367013 countsByYear W20853670132020 @default.
- W2085367013 countsByYear W20853670132021 @default.
- W2085367013 crossrefType "journal-article" @default.
- W2085367013 hasAuthorship W2085367013A5027121686 @default.
- W2085367013 hasAuthorship W2085367013A5033869623 @default.
- W2085367013 hasConcept C12554922 @default.
- W2085367013 hasConcept C126322002 @default.
- W2085367013 hasConcept C131453863 @default.
- W2085367013 hasConcept C134018914 @default.
- W2085367013 hasConcept C170493617 @default.
- W2085367013 hasConcept C185592680 @default.
- W2085367013 hasConcept C2776919887 @default.
- W2085367013 hasConcept C2776992346 @default.
- W2085367013 hasConcept C2779395532 @default.
- W2085367013 hasConcept C2779591629 @default.
- W2085367013 hasConcept C2779768347 @default.
- W2085367013 hasConcept C2780419564 @default.
- W2085367013 hasConcept C2780733407 @default.
- W2085367013 hasConcept C2781128415 @default.
- W2085367013 hasConcept C2992686903 @default.
- W2085367013 hasConcept C55493867 @default.
- W2085367013 hasConcept C555293320 @default.
- W2085367013 hasConcept C66974803 @default.
- W2085367013 hasConcept C71240020 @default.
- W2085367013 hasConcept C71924100 @default.
- W2085367013 hasConcept C79879829 @default.
- W2085367013 hasConcept C83743174 @default.
- W2085367013 hasConcept C86803240 @default.
- W2085367013 hasConcept C95444343 @default.
- W2085367013 hasConcept C98274493 @default.
- W2085367013 hasConceptScore W2085367013C12554922 @default.
- W2085367013 hasConceptScore W2085367013C126322002 @default.
- W2085367013 hasConceptScore W2085367013C131453863 @default.
- W2085367013 hasConceptScore W2085367013C134018914 @default.
- W2085367013 hasConceptScore W2085367013C170493617 @default.
- W2085367013 hasConceptScore W2085367013C185592680 @default.
- W2085367013 hasConceptScore W2085367013C2776919887 @default.
- W2085367013 hasConceptScore W2085367013C2776992346 @default.
- W2085367013 hasConceptScore W2085367013C2779395532 @default.
- W2085367013 hasConceptScore W2085367013C2779591629 @default.
- W2085367013 hasConceptScore W2085367013C2779768347 @default.
- W2085367013 hasConceptScore W2085367013C2780419564 @default.
- W2085367013 hasConceptScore W2085367013C2780733407 @default.
- W2085367013 hasConceptScore W2085367013C2781128415 @default.
- W2085367013 hasConceptScore W2085367013C2992686903 @default.
- W2085367013 hasConceptScore W2085367013C55493867 @default.
- W2085367013 hasConceptScore W2085367013C555293320 @default.
- W2085367013 hasConceptScore W2085367013C66974803 @default.
- W2085367013 hasConceptScore W2085367013C71240020 @default.
- W2085367013 hasConceptScore W2085367013C71924100 @default.
- W2085367013 hasConceptScore W2085367013C79879829 @default.
- W2085367013 hasConceptScore W2085367013C83743174 @default.
- W2085367013 hasConceptScore W2085367013C86803240 @default.
- W2085367013 hasConceptScore W2085367013C95444343 @default.
- W2085367013 hasConceptScore W2085367013C98274493 @default.
- W2085367013 hasIssue "1" @default.
- W2085367013 hasLocation W20853670131 @default.
- W2085367013 hasLocation W20853670132 @default.
- W2085367013 hasOpenAccess W2085367013 @default.
- W2085367013 hasPrimaryLocation W20853670131 @default.
- W2085367013 hasRelatedWork W1544527487 @default.
- W2085367013 hasRelatedWork W1684778245 @default.
- W2085367013 hasRelatedWork W1965430847 @default.
- W2085367013 hasRelatedWork W2016703981 @default.
- W2085367013 hasRelatedWork W2017140757 @default.
- W2085367013 hasRelatedWork W2073779099 @default.
- W2085367013 hasRelatedWork W2085367013 @default.
- W2085367013 hasRelatedWork W2104873538 @default.
- W2085367013 hasRelatedWork W2131577505 @default.
- W2085367013 hasRelatedWork W2138087472 @default.
- W2085367013 hasVolume "31" @default.
- W2085367013 isParatext "false" @default.
- W2085367013 isRetracted "false" @default.
- W2085367013 magId "2085367013" @default.
- W2085367013 workType "article" @default.