FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085367103> ?p ?o ?g. }

• W2085367103 endingPage "29" @default.
• W2085367103 startingPage "26" @default.
• W2085367103 abstract "Wnts have been shown to provide a posteriorizing signal that has to be repressed in the specification of vertebrate forebrain region. Previous studies have shown that Wnt activation by LiCl treatment causes an expansion of optic stalk and mid-hindbrain boundary, whereas eye and ventral diencephalon in the forebrain region were reduced. However, the molecular mechanism, by which inhibits Wnt activity in the forebrain remains poorly defined. To investigate relationship between forebrain specification and Wnt signaling, the zebrafish homologue of secreted frizzled related protein1 (sfrp1) has been characterized. The transcripts of sfrp1 are detected in the presumptive forebrain at gastrula and in the ventral telencephalon, ventral diencephalon, midbrain and optic vesicles at 24h after postfertilization (hpf). Overexpression of sfrp1 causes an anteriorization of embryo, with enlarged head and reduced posterior structure as in the embryo overexpressing dominant-negative form of Frizzled8a or Dkk1. Its overexpression restored the eye defects in the Wnt8b-overexpressing embryos, but not in the LiCl-treated embryos. These results suggest that Sfrp1 expressed in the forebrain and eye field plays a critical role in the extracellular events of antagonizing Wnt activity for the forebrain specification." @default.
• W2085367103 created "2016-06-24" @default.
• W2085367103 creator A5004533799 @default.
• W2085367103 creator A5008790587 @default.
• W2085367103 creator A5011278087 @default.
• W2085367103 creator A5015486310 @default.
• W2085367103 creator A5017876650 @default.
• W2085367103 creator A5030341486 @default.
• W2085367103 creator A5063101749 @default.
• W2085367103 creator A5063893860 @default.
• W2085367103 creator A5078773457 @default.
• W2085367103 creator A5078947807 @default.
• W2085367103 date "2007-02-01" @default.
• W2085367103 modified "2023-10-16" @default.
• W2085367103 title "Eye field requires the function of Sfrp1 as a Wnt antagonist" @default.
• W2085367103 cites W1811188705 @default.
• W2085367103 cites W1992178400 @default.
• W2085367103 cites W2037767452 @default.
• W2085367103 cites W2048675800 @default.
• W2085367103 cites W2052970108 @default.
• W2085367103 cites W2060408023 @default.
• W2085367103 cites W2068483959 @default.
• W2085367103 cites W2127280898 @default.
• W2085367103 cites W2133744591 @default.
• W2085367103 cites W2146163922 @default.
• W2085367103 cites W2154527198 @default.
• W2085367103 cites W2395950107 @default.
• W2085367103 doi "https://doi.org/10.1016/j.neulet.2006.12.027" @default.
• W2085367103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17222974" @default.
• W2085367103 hasPublicationYear "2007" @default.
• W2085367103 type Work @default.
• W2085367103 sameAs 2085367103 @default.
• W2085367103 citedByCount "14" @default.
• W2085367103 countsByYear W20853671032012 @default.
• W2085367103 countsByYear W20853671032013 @default.
• W2085367103 countsByYear W20853671032014 @default.
• W2085367103 countsByYear W20853671032015 @default.
• W2085367103 countsByYear W20853671032017 @default.
• W2085367103 countsByYear W20853671032018 @default.
• W2085367103 crossrefType "journal-article" @default.
• W2085367103 hasAuthorship W2085367103A5004533799 @default.
• W2085367103 hasAuthorship W2085367103A5008790587 @default.
• W2085367103 hasAuthorship W2085367103A5011278087 @default.
• W2085367103 hasAuthorship W2085367103A5015486310 @default.
• W2085367103 hasAuthorship W2085367103A5017876650 @default.
• W2085367103 hasAuthorship W2085367103A5030341486 @default.
• W2085367103 hasAuthorship W2085367103A5063101749 @default.
• W2085367103 hasAuthorship W2085367103A5063893860 @default.
• W2085367103 hasAuthorship W2085367103A5078773457 @default.
• W2085367103 hasAuthorship W2085367103A5078947807 @default.
• W2085367103 hasConcept C104317684 @default.
• W2085367103 hasConcept C105702510 @default.
• W2085367103 hasConcept C129536746 @default.
• W2085367103 hasConcept C134018914 @default.
• W2085367103 hasConcept C137620995 @default.
• W2085367103 hasConcept C169760540 @default.
• W2085367103 hasConcept C196843134 @default.
• W2085367103 hasConcept C2775969318 @default.
• W2085367103 hasConcept C2776878037 @default.
• W2085367103 hasConcept C2777075493 @default.
• W2085367103 hasConcept C2779715522 @default.
• W2085367103 hasConcept C529278444 @default.
• W2085367103 hasConcept C533869091 @default.
• W2085367103 hasConcept C54355233 @default.
• W2085367103 hasConcept C552161191 @default.
• W2085367103 hasConcept C62478195 @default.
• W2085367103 hasConcept C86803240 @default.
• W2085367103 hasConcept C87073359 @default.
• W2085367103 hasConcept C95444343 @default.
• W2085367103 hasConceptScore W2085367103C104317684 @default.
• W2085367103 hasConceptScore W2085367103C105702510 @default.
• W2085367103 hasConceptScore W2085367103C129536746 @default.
• W2085367103 hasConceptScore W2085367103C134018914 @default.
• W2085367103 hasConceptScore W2085367103C137620995 @default.
• W2085367103 hasConceptScore W2085367103C169760540 @default.
• W2085367103 hasConceptScore W2085367103C196843134 @default.
• W2085367103 hasConceptScore W2085367103C2775969318 @default.
• W2085367103 hasConceptScore W2085367103C2776878037 @default.
• W2085367103 hasConceptScore W2085367103C2777075493 @default.
• W2085367103 hasConceptScore W2085367103C2779715522 @default.
• W2085367103 hasConceptScore W2085367103C529278444 @default.
• W2085367103 hasConceptScore W2085367103C533869091 @default.
• W2085367103 hasConceptScore W2085367103C54355233 @default.
• W2085367103 hasConceptScore W2085367103C552161191 @default.
• W2085367103 hasConceptScore W2085367103C62478195 @default.
• W2085367103 hasConceptScore W2085367103C86803240 @default.
• W2085367103 hasConceptScore W2085367103C87073359 @default.
• W2085367103 hasConceptScore W2085367103C95444343 @default.
• W2085367103 hasIssue "1" @default.
• W2085367103 hasLocation W20853671031 @default.
• W2085367103 hasLocation W20853671032 @default.
• W2085367103 hasOpenAccess W2085367103 @default.
• W2085367103 hasPrimaryLocation W20853671031 @default.
• W2085367103 hasRelatedWork W1143996359 @default.
• W2085367103 hasRelatedWork W1965207495 @default.
• W2085367103 hasRelatedWork W1980272463 @default.
• W2085367103 hasRelatedWork W1990170805 @default.
• W2085367103 hasRelatedWork W2001183026 @default.

• next