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• W2085367500 abstract "The effects of prolonged treatment with iron chelator (desferrioxamine) on the development of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated mice presented lower levels of parasitemia and reduced mortality rate compared with infected/non-treated animals. The five out of twenty infected/treated mice that survived the acute phase of infection showed negative hemoculture and positive ELISA in the acute and chronic phases and positive PCR in the acute phase: in the chronic phase, three of the animals presented negative PCR. The single surviving infected/non-treated animal exhibited positive hemoculture, PCR and ELISA in both phases of infection. Infected groups presented lower levels of iron in the liver compared with treated/non-infected or non-treated/non-infected animals. The serum iron levels of the infected/non-treated group were higher on the 21st day post-infection in comparison with control and infected/treated groups. These results suggest that decrease of iron in the host leads to T. cruzi infection attenuation." @default.
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• W2085367500 date "2007-09-01" @default.
• W2085367500 modified "2023-10-15" @default.
• W2085367500 title "Trypanosoma cruzi: Treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice" @default.
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• W2085367500 doi "https://doi.org/10.1016/j.exppara.2007.03.006" @default.
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