FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085367783> ?p ?o ?g. }

• W2085367783 endingPage "535" @default.
• W2085367783 startingPage "528" @default.
• W2085367783 abstract "A 160,000 mol wt precursor of the epidermal growth factor (EGF) receptor has been identified in human A-431 carcinoma cells and skin fibroblasts. The presence of one discrete precursor band indicates the presence of a slow processing step. We have determined that this slow processing step involves the conversion of high mannose N-linked oligosaccharides on the receptor precursor to primarily complex oligosaccharides on the mature form of the receptor. This is shown by 1) the presence of fucose, a characteristic terminal sugar of complex oligosaccharides, in only the mature receptor and by 2) the susceptibility of the precursor to digestion with endoglycosidase H, which cleaves high mannose N-linked oligosaccharides, but not complex oligosaccharides from glycoproteins. The precursor to mature receptor transition half-time is 1.7 h in A-431 cells. This long transition half-time causes an accumulation of approximately 7.2 X 10(5) precursor molecules per cell (approximately 12% of the total population of EGF receptors). The net quantity of mature EGF receptors, but not of receptor precursors, is reduced when EGF is added to the culture medium of A-431 cells. The presence of EGF in the growth medium also decreases electrophoretic migration (as a result of increased phosphate incorporation) of the mature receptor, but not that of the precursor. The EGF-insensitive state of the precursor is most likely due to its intracellular location." @default.
• W2085367783 created "2016-06-24" @default.
• W2085367783 creator A5004214431 @default.
• W2085367783 creator A5008190196 @default.
• W2085367783 creator A5067111986 @default.
• W2085367783 date "1985-02-01" @default.
• W2085367783 modified "2023-09-27" @default.
• W2085367783 title "Biosynthesis of the Epidermal Growth Factor Receptor in Cultured Human Cells*" @default.
• W2085367783 cites W1498071142 @default.
• W2085367783 cites W1501383613 @default.
• W2085367783 cites W1521840182 @default.
• W2085367783 cites W1529315337 @default.
• W2085367783 cites W1567148937 @default.
• W2085367783 cites W1894641937 @default.
• W2085367783 cites W1923874092 @default.
• W2085367783 cites W1965316807 @default.
• W2085367783 cites W1965371391 @default.
• W2085367783 cites W1965697811 @default.
• W2085367783 cites W1981339271 @default.
• W2085367783 cites W1984351623 @default.
• W2085367783 cites W1986167530 @default.
• W2085367783 cites W1996683778 @default.
• W2085367783 cites W2002957080 @default.
• W2085367783 cites W2032714210 @default.
• W2085367783 cites W2035432922 @default.
• W2085367783 cites W2066997031 @default.
• W2085367783 cites W2072999479 @default.
• W2085367783 cites W2085769544 @default.
• W2085367783 cites W2115388678 @default.
• W2085367783 cites W2120179279 @default.
• W2085367783 cites W944969987 @default.
• W2085367783 cites W97075052 @default.
• W2085367783 doi "https://doi.org/10.1210/endo-116-2-528" @default.
• W2085367783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2981666" @default.
• W2085367783 hasPublicationYear "1985" @default.
• W2085367783 type Work @default.
• W2085367783 sameAs 2085367783 @default.
• W2085367783 citedByCount "35" @default.
• W2085367783 countsByYear W20853677832016 @default.
• W2085367783 crossrefType "journal-article" @default.
• W2085367783 hasAuthorship W2085367783A5004214431 @default.
• W2085367783 hasAuthorship W2085367783A5008190196 @default.
• W2085367783 hasAuthorship W2085367783A5067111986 @default.
• W2085367783 hasConcept C108625454 @default.
• W2085367783 hasConcept C119062480 @default.
• W2085367783 hasConcept C126322002 @default.
• W2085367783 hasConcept C134018914 @default.
• W2085367783 hasConcept C144024400 @default.
• W2085367783 hasConcept C144174609 @default.
• W2085367783 hasConcept C1491633281 @default.
• W2085367783 hasConcept C149923435 @default.
• W2085367783 hasConcept C170493617 @default.
• W2085367783 hasConcept C185592680 @default.
• W2085367783 hasConcept C21936154 @default.
• W2085367783 hasConcept C2775960820 @default.
• W2085367783 hasConcept C2776362946 @default.
• W2085367783 hasConcept C2776841590 @default.
• W2085367783 hasConcept C2779571893 @default.
• W2085367783 hasConcept C2908647359 @default.
• W2085367783 hasConcept C55493867 @default.
• W2085367783 hasConcept C71924100 @default.
• W2085367783 hasConcept C86803240 @default.
• W2085367783 hasConcept C95444343 @default.
• W2085367783 hasConceptScore W2085367783C108625454 @default.
• W2085367783 hasConceptScore W2085367783C119062480 @default.
• W2085367783 hasConceptScore W2085367783C126322002 @default.
• W2085367783 hasConceptScore W2085367783C134018914 @default.
• W2085367783 hasConceptScore W2085367783C144024400 @default.
• W2085367783 hasConceptScore W2085367783C144174609 @default.
• W2085367783 hasConceptScore W2085367783C1491633281 @default.
• W2085367783 hasConceptScore W2085367783C149923435 @default.
• W2085367783 hasConceptScore W2085367783C170493617 @default.
• W2085367783 hasConceptScore W2085367783C185592680 @default.
• W2085367783 hasConceptScore W2085367783C21936154 @default.
• W2085367783 hasConceptScore W2085367783C2775960820 @default.
• W2085367783 hasConceptScore W2085367783C2776362946 @default.
• W2085367783 hasConceptScore W2085367783C2776841590 @default.
• W2085367783 hasConceptScore W2085367783C2779571893 @default.
• W2085367783 hasConceptScore W2085367783C2908647359 @default.
• W2085367783 hasConceptScore W2085367783C55493867 @default.
• W2085367783 hasConceptScore W2085367783C71924100 @default.
• W2085367783 hasConceptScore W2085367783C86803240 @default.
• W2085367783 hasConceptScore W2085367783C95444343 @default.
• W2085367783 hasIssue "2" @default.
• W2085367783 hasLocation W20853677831 @default.
• W2085367783 hasLocation W20853677832 @default.
• W2085367783 hasOpenAccess W2085367783 @default.
• W2085367783 hasPrimaryLocation W20853677831 @default.
• W2085367783 hasRelatedWork W1999660566 @default.
• W2085367783 hasRelatedWork W2011400055 @default.
• W2085367783 hasRelatedWork W2018368842 @default.
• W2085367783 hasRelatedWork W2085367783 @default.
• W2085367783 hasRelatedWork W2087733961 @default.
• W2085367783 hasRelatedWork W2126532023 @default.
• W2085367783 hasRelatedWork W2144562624 @default.
• W2085367783 hasRelatedWork W2171223757 @default.
• W2085367783 hasRelatedWork W4236934633 @default.
• W2085367783 hasRelatedWork W1995193459 @default.

• next