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- W2085375894 abstract "Ectopic expression of oncogenic H-Ras in cells results in increases of cell susceptibility to the anticancer agent FR901228. Investigating the roles of Ras-induced pathways in FR901228-induced apoptosis, we have found that the phosphatidylinositol 3-kinase pathway plays an anti-apoptotic role, whereas the stress-activated protein kinase p38 pathway plays a pro-apoptotic role in FR901228-induced apoptosis. Interestingly, the extracellular signal-regulated kinase (ERK) pathway plays an anti-apoptotic role in non-transformed cells; however, it plays a pro-apoptotic role in Ras-transformed cells in response to FR901228 treatment. An essential role of the ERK pathway in regulating caspase-3 contents may contribute to its pro-apoptotic role in Ras-transformed cells." @default.
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- W2085375894 date "2004-11-28" @default.
- W2085375894 modified "2023-10-14" @default.
- W2085375894 title "Distinct roles of the ERK pathway in modulating apoptosis of Ras‐transformed and non‐transformed cells induced by anticancer agent FR901228" @default.
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- W2085375894 doi "https://doi.org/10.1016/j.febslet.2004.11.050" @default.
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