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- W2085376455 abstract "The perinuclear actin cap (or actin cap) is a recently characterized cytoskeletal organelle composed of thick, parallel, and highly contractile acto-myosin filaments that are specifically anchored to the apical surface of the interphase nucleus. The actin cap is present in a wide range of adherent eukaryotic cells, but is disrupted in several human diseases, including laminopathies and cancer. Through its large terminating focal adhesions and anchorage to the nuclear lamina and nuclear envelope through LINC complexes, the perinuclear actin cap plays a critical role both in mechanosensation and mechanotransduction, the ability of cells to sense changes in matrix compliance and to respond to mechanical forces, respectively." @default.
- W2085376455 created "2016-06-24" @default.
- W2085376455 creator A5003835601 @default.
- W2085376455 creator A5023206720 @default.
- W2085376455 creator A5048842521 @default.
- W2085376455 date "2013-01-01" @default.
- W2085376455 modified "2023-10-17" @default.
- W2085376455 title "The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction" @default.
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- W2085376455 doi "https://doi.org/10.1039/c3sm50798j" @default.
- W2085376455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3733260" @default.
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