FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085382099> ?p ?o ?g. }

• W2085382099 endingPage "1100" @default.
• W2085382099 startingPage "1093" @default.
• W2085382099 abstract "Nitric oxide (NO) and its by-products modulate many physiological functions of skeletal muscle including blood flow, metabolism, glucose uptake, and contractile function. However, growing evidence suggests that an overproduction of nitric oxide contributes to muscle wasting in a number of pathologies including chronic heart failure, sepsis, COPD, muscular dystrophy, and extreme disuse. Limited data point to the potential of inhibition various enzymes by reactive nitrogen species (RNS), including NO and its downstream products such as peroxynitrite, primarily in purified systems. We hypothesized that exposure of skeletal muscle to RNS donors would reduce or downregulate activities of the crucial antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX). Diaphragm muscle fiber bundles were extracted from 4-month-old Fischer-344 rats and, in a series of experiments, exposed to either (a) 0 (control), 1, or 5 mM diethylamine NONOate (DEANO: NO donor); (b) 0, 100, 500μM, or 1 mM sodium nitroprusside (SNP: NO donor); (c) 0 or 2 mM S-nitroso-acetylpenicillamine (SNAP: NO donor); or (d) 0 or 500μM SIN-1 (peroxynitrite donor) for 60 min. DEANO resulted in a 50% reduction in CAT, GPX, and a dose-dependent inhibition of Cu, Zn-SOD. SNP resulted in significantly lower activities for total SOD, Mn-SOD isoform, Cu, Zn-SOD isoform, CAT, and GPX in a dose-dependent fashion. Two millimolar SNAP and 500μM SIN-1 also resulted in a large and significant inhibition of total SOD and CAT. These data indicate that reactive nitrogen species impair antioxidant enzyme function in an RNS donor-specific and dose-dependent manner and are consistent with the hypothesis that excess RNS production contributes to skeletal muscle oxidative stress and muscle dysfunction." @default.
• W2085382099 created "2016-06-24" @default.
• W2085382099 creator A5003872915 @default.
• W2085382099 creator A5041860600 @default.
• W2085382099 date "2002-06-01" @default.
• W2085382099 modified "2023-10-14" @default.
• W2085382099 title "Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors" @default.
• W2085382099 cites W1481433938 @default.
• W2085382099 cites W1546592314 @default.
• W2085382099 cites W1821918060 @default.
• W2085382099 cites W191793640 @default.
• W2085382099 cites W1969233885 @default.
• W2085382099 cites W1972438028 @default.
• W2085382099 cites W1972652247 @default.
• W2085382099 cites W1977573041 @default.
• W2085382099 cites W1983436629 @default.
• W2085382099 cites W1996568659 @default.
• W2085382099 cites W2004052382 @default.
• W2085382099 cites W2006092129 @default.
• W2085382099 cites W2010724047 @default.
• W2085382099 cites W2016232877 @default.
• W2085382099 cites W2016335663 @default.
• W2085382099 cites W2022276077 @default.
• W2085382099 cites W2024994588 @default.
• W2085382099 cites W2039045136 @default.
• W2085382099 cites W2044358861 @default.
• W2085382099 cites W2046100558 @default.
• W2085382099 cites W2049413621 @default.
• W2085382099 cites W2056794597 @default.
• W2085382099 cites W2060786201 @default.
• W2085382099 cites W2064619021 @default.
• W2085382099 cites W2066953042 @default.
• W2085382099 cites W2073540673 @default.
• W2085382099 cites W2087224892 @default.
• W2085382099 cites W2089727847 @default.
• W2085382099 cites W2100822050 @default.
• W2085382099 cites W2143937527 @default.
• W2085382099 cites W2146048992 @default.
• W2085382099 cites W2167248595 @default.
• W2085382099 cites W2259482999 @default.
• W2085382099 cites W2264085384 @default.
• W2085382099 cites W2334924346 @default.
• W2085382099 cites W2416415283 @default.
• W2085382099 cites W4236561580 @default.
• W2085382099 cites W4316093067 @default.
• W2085382099 cites W87195670 @default.
• W2085382099 cites W96614748 @default.
• W2085382099 doi "https://doi.org/10.1016/s0006-291x(02)00602-2" @default.
• W2085382099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12074589" @default.
• W2085382099 hasPublicationYear "2002" @default.
• W2085382099 type Work @default.
• W2085382099 sameAs 2085382099 @default.
• W2085382099 citedByCount "65" @default.
• W2085382099 countsByYear W20853820992014 @default.
• W2085382099 countsByYear W20853820992015 @default.
• W2085382099 countsByYear W20853820992016 @default.
• W2085382099 countsByYear W20853820992017 @default.
• W2085382099 countsByYear W20853820992018 @default.
• W2085382099 countsByYear W20853820992019 @default.
• W2085382099 countsByYear W20853820992022 @default.
• W2085382099 countsByYear W20853820992023 @default.
• W2085382099 crossrefType "journal-article" @default.
• W2085382099 hasAuthorship W2085382099A5003872915 @default.
• W2085382099 hasAuthorship W2085382099A5041860600 @default.
• W2085382099 hasConcept C126322002 @default.
• W2085382099 hasConcept C134018914 @default.
• W2085382099 hasConcept C178790620 @default.
• W2085382099 hasConcept C181199279 @default.
• W2085382099 hasConcept C185592680 @default.
• W2085382099 hasConcept C2775838275 @default.
• W2085382099 hasConcept C2778004101 @default.
• W2085382099 hasConcept C2778760513 @default.
• W2085382099 hasConcept C2778784160 @default.
• W2085382099 hasConcept C2778979269 @default.
• W2085382099 hasConcept C2779525624 @default.
• W2085382099 hasConcept C2779610285 @default.
• W2085382099 hasConcept C2779959927 @default.
• W2085382099 hasConcept C2780795997 @default.
• W2085382099 hasConcept C48349386 @default.
• W2085382099 hasConcept C519581460 @default.
• W2085382099 hasConcept C55493867 @default.
• W2085382099 hasConcept C71924100 @default.
• W2085382099 hasConcept C86803240 @default.
• W2085382099 hasConceptScore W2085382099C126322002 @default.
• W2085382099 hasConceptScore W2085382099C134018914 @default.
• W2085382099 hasConceptScore W2085382099C178790620 @default.
• W2085382099 hasConceptScore W2085382099C181199279 @default.
• W2085382099 hasConceptScore W2085382099C185592680 @default.
• W2085382099 hasConceptScore W2085382099C2775838275 @default.
• W2085382099 hasConceptScore W2085382099C2778004101 @default.
• W2085382099 hasConceptScore W2085382099C2778760513 @default.
• W2085382099 hasConceptScore W2085382099C2778784160 @default.
• W2085382099 hasConceptScore W2085382099C2778979269 @default.
• W2085382099 hasConceptScore W2085382099C2779525624 @default.
• W2085382099 hasConceptScore W2085382099C2779610285 @default.
• W2085382099 hasConceptScore W2085382099C2779959927 @default.
• W2085382099 hasConceptScore W2085382099C2780795997 @default.
• W2085382099 hasConceptScore W2085382099C48349386 @default.

• next