Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085382843> ?p ?o ?g. }
- W2085382843 endingPage "156" @default.
- W2085382843 startingPage "145" @default.
- W2085382843 abstract "Evidence of normalized auditory P50 suppression with acute nicotine in schizophrenia has supported the contention that elevated smoking rates in this disorder may be an attempt to correct a nicotinic receptor pathophysiology that may underly impaired sensory gating in these patients. There is very little information regarding the neurochemical or genetic pathways through which nicotine regulates P50 amplitude and its suppression in human studies. In a randomized, double-blind, placebo-controlled design with 24 non-smokers, this study examined the influence of TaqIA dopamine D2 receptor gene polymorphisms on P50 and its inhibition during nicotine gum (6 mg) administration. Within a paired click (S(1)-S(2)) paradigm, placebo treated A1(+) and A1(-) allele groups differed with respect to P50 amplitude and gating. While nicotine (relative to placebo) attenuated S(1) P50 amplitude in A1(+) allele carriers, in the A1(-) carriers it increased S(2) P50 amplitude and increased P50 gating as indexed by an augmented gating difference wave (GDW). These findings suggest that nicotine exerts mixed gating properties in healthy nicotine naive volunteers and that dopamine functions to alter both P50 and its gating as well as their response to acute nicotine agonist treatment." @default.
- W2085382843 created "2016-06-24" @default.
- W2085382843 creator A5002795098 @default.
- W2085382843 creator A5037323059 @default.
- W2085382843 creator A5059065233 @default.
- W2085382843 creator A5062184570 @default.
- W2085382843 date "2010-03-01" @default.
- W2085382843 modified "2023-09-25" @default.
- W2085382843 title "Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine D2 receptor gene polymorphism" @default.
- W2085382843 cites W1483329522 @default.
- W2085382843 cites W1532317254 @default.
- W2085382843 cites W1568198343 @default.
- W2085382843 cites W1645987675 @default.
- W2085382843 cites W1962756033 @default.
- W2085382843 cites W1964697111 @default.
- W2085382843 cites W1964756819 @default.
- W2085382843 cites W1964979617 @default.
- W2085382843 cites W1965198880 @default.
- W2085382843 cites W1965516783 @default.
- W2085382843 cites W1967187196 @default.
- W2085382843 cites W1967443916 @default.
- W2085382843 cites W1968475159 @default.
- W2085382843 cites W1973661620 @default.
- W2085382843 cites W1974200459 @default.
- W2085382843 cites W1974321496 @default.
- W2085382843 cites W1977448273 @default.
- W2085382843 cites W1978005528 @default.
- W2085382843 cites W1978331418 @default.
- W2085382843 cites W1978797635 @default.
- W2085382843 cites W1979596511 @default.
- W2085382843 cites W1980215843 @default.
- W2085382843 cites W1980298140 @default.
- W2085382843 cites W1980446593 @default.
- W2085382843 cites W1983357248 @default.
- W2085382843 cites W1985314523 @default.
- W2085382843 cites W1985748151 @default.
- W2085382843 cites W1989634408 @default.
- W2085382843 cites W1990380087 @default.
- W2085382843 cites W1992434575 @default.
- W2085382843 cites W1994037263 @default.
- W2085382843 cites W1994705883 @default.
- W2085382843 cites W1994905981 @default.
- W2085382843 cites W1997129578 @default.
- W2085382843 cites W1998452434 @default.
- W2085382843 cites W2000409641 @default.
- W2085382843 cites W2000620904 @default.
- W2085382843 cites W2000732720 @default.
- W2085382843 cites W2002028713 @default.
- W2085382843 cites W2002178426 @default.
- W2085382843 cites W2003441351 @default.
- W2085382843 cites W2004990019 @default.
- W2085382843 cites W2006670955 @default.
- W2085382843 cites W2014598698 @default.
- W2085382843 cites W2015292105 @default.
- W2085382843 cites W2016098801 @default.
- W2085382843 cites W2018242468 @default.
- W2085382843 cites W2021139758 @default.
- W2085382843 cites W2022251735 @default.
- W2085382843 cites W2022961682 @default.
- W2085382843 cites W2023076733 @default.
- W2085382843 cites W2024566705 @default.
- W2085382843 cites W2024916359 @default.
- W2085382843 cites W2025759097 @default.
- W2085382843 cites W2026686521 @default.
- W2085382843 cites W2027150892 @default.
- W2085382843 cites W2027238098 @default.
- W2085382843 cites W2027977900 @default.
- W2085382843 cites W2032395354 @default.
- W2085382843 cites W2039131285 @default.
- W2085382843 cites W2040156024 @default.
- W2085382843 cites W2041796249 @default.
- W2085382843 cites W2045930618 @default.
- W2085382843 cites W2047877800 @default.
- W2085382843 cites W2049198374 @default.
- W2085382843 cites W2050524613 @default.
- W2085382843 cites W2052103983 @default.
- W2085382843 cites W2052161329 @default.
- W2085382843 cites W2054744484 @default.
- W2085382843 cites W2058267722 @default.
- W2085382843 cites W2061703777 @default.
- W2085382843 cites W2063778638 @default.
- W2085382843 cites W2063793718 @default.
- W2085382843 cites W2063844578 @default.
- W2085382843 cites W2065841438 @default.
- W2085382843 cites W2067014755 @default.
- W2085382843 cites W2070882508 @default.
- W2085382843 cites W2071228204 @default.
- W2085382843 cites W2074080376 @default.
- W2085382843 cites W2075362165 @default.
- W2085382843 cites W2076778800 @default.
- W2085382843 cites W2078736215 @default.
- W2085382843 cites W2079712833 @default.
- W2085382843 cites W2081044594 @default.
- W2085382843 cites W2081617660 @default.
- W2085382843 cites W2081800196 @default.
- W2085382843 cites W2083907790 @default.
- W2085382843 cites W2084596338 @default.
- W2085382843 cites W2090019512 @default.