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• W2085384621 abstract "A major goal in the study of human evolution is to identify key genetic changes which occurred over the course of primate evolution. According to one school of thought, many such changes are likely to be found in noncoding sequence. An approach to identifying these involves comparing multiple genomes to identify conserved regions with an accelerated substitution rate in a particular lineage. Such acceleration could be the result of positive selection. Here we develop a likelihood ratio test method to identify such regions. We apply it not only to the human terminal lineage, as has been done in previous studies, but also to a number of other branches in the primate tree. We present the top scoring elements, and compare our results with previous studies. We also present resequencing data from one particular element accelerated on the human lineage. These data indicate that the element lies in a region of low polymorphism in humans, consistent with the possibility of a recent selective sweep. They also show that the AT to GC bias for polymorphism in this region differs dramatically from that for substitutions. Our results suggest that screens of this type will be helpful in unraveling the complex set of changes which occurred during primate evolution." @default.
• W2085384621 created "2016-06-24" @default.
• W2085384621 creator A5010020076 @default.
• W2085384621 creator A5081946675 @default.
• W2085384621 date "2008-01-01" @default.
• W2085384621 modified "2023-10-06" @default.
• W2085384621 title "A genome-wide screen for noncoding elements important in primate evolution" @default.
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• W2085384621 doi "https://doi.org/10.1186/1471-2148-8-17" @default.
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