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• W2085387615 abstract "<i>Background/Aims:</i> Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT₃ receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). <i>Methods:</i> The present study was designed to explore the effect of 3 serotonin 5-HT₃ receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. <i>Results:</i> Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. <i>Conclusion:</i> These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery." @default.
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• W2085387615 date "2009-01-01" @default.
• W2085387615 modified "2023-10-16" @default.
• W2085387615 title "Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT₃ Receptor Antagonists in Mice" @default.
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• W2085387615 doi "https://doi.org/10.1159/000207448" @default.
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