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- W2085389872 abstract "Abstract Two types of mutants, those resistant to the base analog 5-bromo-2′-deoxyuridine (BrdU) and somatic regenerator (SR) mutants, have been analyzed in Volvox carteri. In somatic regenerator mutants, the somatic cells which are normally terminally differentiated dedifferentiate and regenerate gonidia [ Sessoms, A., and Huskey, R. J. (1973). Proc. Nat. Acad. Sci. USA 70, 1335–1338 ; Starr, R. C. (1970). Develop. Biol. Suppl. 4, 59–100 ]. The SR phenotype allows recovery of SR mutations arising in somatic cells, since such somatic cells would regenerate gonidia and give rise to mutant clones. Mutants of any phenotype other than SR can only be recovered if the mutation first appears in a gonidium. Since the somatic cells are 100-fold more numerous than reproductive cells (gonidia), we have determined the spontaneous frequency of both somatic regenerator mutants and mutations to BrdU resistance in order to determine if the SR mutation exerts its effect in the gonidium or in the somatic cell. The two frequencies were found to be nearly identical, suggesting that the SR mutation must first appear in a gonidium in order to be expressed." @default.
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- W2085389872 date "1978-09-01" @default.
- W2085389872 modified "2023-09-27" @default.
- W2085389872 title "Spontaneous frequency of a developmental mutant in Volvox" @default.
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- W2085389872 doi "https://doi.org/10.1016/0012-1606(78)90290-7" @default.
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