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• W2085389945 abstract "A novel series of indole/indazole-aminopyrimidines was designed and synthesized with an aim to achieve optimal potency and selectivity for the c-Jun kinase family or JNKs. Structure guided design was used to optimize the series resulting in a significant potency improvement. The best compound (17) has IC50 of 3 nM for JNK1 and 20 nM for JNK2, with greater than 40-fold selectivity against other kinases with good physicochemical and pharmacokinetic properties." @default.
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• W2085389945 date "2013-06-01" @default.
• W2085389945 modified "2023-09-27" @default.
• W2085389945 title "Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties" @default.
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• W2085389945 doi "https://doi.org/10.1016/j.bmcl.2013.04.029" @default.
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