Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085392796> ?p ?o ?g. }
- W2085392796 endingPage "602" @default.
- W2085392796 startingPage "588" @default.
- W2085392796 abstract "Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well known, but the cellular mechanisms have remained ill defined. We established imaging methodology for live visualization of embryonic skin explants during the first wave of hair placode formation. We found that the vast majority of placodal cells were nonproliferative throughout morphogenesis. We show that cell compaction and centripetal migration are the main cellular mechanisms associated with hair placode morphogenesis and that inhibition of actin remodeling suppresses placode formation. Stimulation of both ectodysplasin/NF-κB and Wnt/β-catenin signaling increased cell motility and the number of cells committed to placodal fate. Thus, cell fate choices and morphogenetic events are controlled by the same molecular pathways, providing the framework for coordination of these two processes." @default.
- W2085392796 created "2016-06-24" @default.
- W2085392796 creator A5016570232 @default.
- W2085392796 creator A5017909726 @default.
- W2085392796 creator A5018452964 @default.
- W2085392796 creator A5052724584 @default.
- W2085392796 creator A5059737089 @default.
- W2085392796 creator A5060662450 @default.
- W2085392796 creator A5077664098 @default.
- W2085392796 creator A5085690942 @default.
- W2085392796 date "2014-03-01" @default.
- W2085392796 modified "2023-10-03" @default.
- W2085392796 title "Directional Cell Migration, but Not Proliferation, Drives Hair Placode Morphogenesis" @default.
- W2085392796 cites W1509829936 @default.
- W2085392796 cites W1548753322 @default.
- W2085392796 cites W1965852206 @default.
- W2085392796 cites W1976459088 @default.
- W2085392796 cites W1982645824 @default.
- W2085392796 cites W1986346221 @default.
- W2085392796 cites W1987222740 @default.
- W2085392796 cites W1988699784 @default.
- W2085392796 cites W1991075591 @default.
- W2085392796 cites W1991382572 @default.
- W2085392796 cites W1992635050 @default.
- W2085392796 cites W1995508961 @default.
- W2085392796 cites W1996435746 @default.
- W2085392796 cites W1997627685 @default.
- W2085392796 cites W2001588444 @default.
- W2085392796 cites W2011437456 @default.
- W2085392796 cites W2011625596 @default.
- W2085392796 cites W2017664010 @default.
- W2085392796 cites W2039233756 @default.
- W2085392796 cites W2044182000 @default.
- W2085392796 cites W2047580046 @default.
- W2085392796 cites W2048252195 @default.
- W2085392796 cites W2053844922 @default.
- W2085392796 cites W2054439316 @default.
- W2085392796 cites W2056210035 @default.
- W2085392796 cites W2062336866 @default.
- W2085392796 cites W2062985351 @default.
- W2085392796 cites W2063452242 @default.
- W2085392796 cites W2071313744 @default.
- W2085392796 cites W2071605378 @default.
- W2085392796 cites W2091308414 @default.
- W2085392796 cites W2094618453 @default.
- W2085392796 cites W2099331689 @default.
- W2085392796 cites W2106197320 @default.
- W2085392796 cites W2108600529 @default.
- W2085392796 cites W2135200683 @default.
- W2085392796 cites W2137031731 @default.
- W2085392796 cites W2142941757 @default.
- W2085392796 cites W2154473845 @default.
- W2085392796 cites W2161241783 @default.
- W2085392796 cites W332047183 @default.
- W2085392796 doi "https://doi.org/10.1016/j.devcel.2014.02.003" @default.
- W2085392796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24636260" @default.
- W2085392796 hasPublicationYear "2014" @default.
- W2085392796 type Work @default.
- W2085392796 sameAs 2085392796 @default.
- W2085392796 citedByCount "96" @default.
- W2085392796 countsByYear W20853927962014 @default.
- W2085392796 countsByYear W20853927962015 @default.
- W2085392796 countsByYear W20853927962016 @default.
- W2085392796 countsByYear W20853927962017 @default.
- W2085392796 countsByYear W20853927962018 @default.
- W2085392796 countsByYear W20853927962019 @default.
- W2085392796 countsByYear W20853927962020 @default.
- W2085392796 countsByYear W20853927962021 @default.
- W2085392796 countsByYear W20853927962022 @default.
- W2085392796 countsByYear W20853927962023 @default.
- W2085392796 crossrefType "journal-article" @default.
- W2085392796 hasAuthorship W2085392796A5016570232 @default.
- W2085392796 hasAuthorship W2085392796A5017909726 @default.
- W2085392796 hasAuthorship W2085392796A5018452964 @default.
- W2085392796 hasAuthorship W2085392796A5052724584 @default.
- W2085392796 hasAuthorship W2085392796A5059737089 @default.
- W2085392796 hasAuthorship W2085392796A5060662450 @default.
- W2085392796 hasAuthorship W2085392796A5077664098 @default.
- W2085392796 hasAuthorship W2085392796A5085690942 @default.
- W2085392796 hasBestOaLocation W20853927961 @default.
- W2085392796 hasConcept C104317684 @default.
- W2085392796 hasConcept C137620995 @default.
- W2085392796 hasConcept C137738243 @default.
- W2085392796 hasConcept C1491633281 @default.
- W2085392796 hasConcept C40692019 @default.
- W2085392796 hasConcept C54355233 @default.
- W2085392796 hasConcept C62478195 @default.
- W2085392796 hasConcept C86803240 @default.
- W2085392796 hasConcept C95444343 @default.
- W2085392796 hasConceptScore W2085392796C104317684 @default.
- W2085392796 hasConceptScore W2085392796C137620995 @default.
- W2085392796 hasConceptScore W2085392796C137738243 @default.
- W2085392796 hasConceptScore W2085392796C1491633281 @default.
- W2085392796 hasConceptScore W2085392796C40692019 @default.
- W2085392796 hasConceptScore W2085392796C54355233 @default.
- W2085392796 hasConceptScore W2085392796C62478195 @default.
- W2085392796 hasConceptScore W2085392796C86803240 @default.
- W2085392796 hasConceptScore W2085392796C95444343 @default.