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- W2085398802 abstract "We compared the effect on primary vaccination plaque-reduction neutralization 80% titers (PRNT80) responses of same-day administration (at different injection sites) of two similar investigational inactivated alphavirus vaccines, eastern equine encephalitis (EEE) vaccine (TSI-GSD 104) and western equine encephalitis (WEE) vaccine (TSI-GSD 210) to separate administration. Overall, primary response rate for EEE vaccine was 524/796 (66%) and overall primary response rate for WEE vaccine was 291/695 (42%). EEE vaccine same-day administration yielded a 59% response rate and a responder geometric mean titer (GMT) = 89 while separate administration yielded a response rate of 69% and a responder GMT = 119. WEE vaccine same-day administration yielded a 30% response rate and a responder GMT = 53 while separate administration yielded a response rate of 54% and a responder GMT = 79. EEE response rates for same-day administration (group A) vs. non-same-day administration (group B) were significantly affected by gender. A logistic regression model predicting response to EEE comparing group B to group A for females yielded an OR = 4.10 (95% CL 1.97–8.55; p = .0002) and for males yielded an OR = 1.25 (95% CL 0.76–2.07; p = .3768). WEE response rates for same-day administration vs. non-same-day administration were independent of gender. A logistic regression model predicting response to WEE comparing group B to group A yielded an OR = 2.14 (95% CL 1.22–3.73; p = .0077). We report immune interference occurring with same-day administration of two completely separate formalin inactivated viral vaccines in humans. These findings combined with the findings of others regarding immune interference would argue for a renewed emphasis on studying the immunological mechanisms of induction of inactivated viral vaccine protection." @default.
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- W2085398802 date "2012-11-01" @default.
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- W2085398802 title "Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: Eastern equine and western equine encephalitis" @default.
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- W2085398802 doi "https://doi.org/10.1016/j.vaccine.2012.09.049" @default.
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