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- W2085403911 abstract "Salvia miltiorrhiza (SM, Danshen), a traditional Chinese herbal drug, has been widely used for hundreds of years to treat coronary artery disease. We studied the effects of SM on the L-type Ca2+ current (ICa-L) with whole-cell patch-clamp technique in rat ventricular myocytes, and its influence on Ca2+ transient and contractility using video-based edge detection and dual excitation fluorescence photomultiplier systems as well. Exposure to SM solution caused a concentration- and voltage-dependent blockade of ICa-L, and the dose of SM solution (10 g/l) decreased the maximal inhibitory effect of 35.2±1.2%. However, SM solution did not significantly change the current–voltage relationship or reversal potential of ICa-L, nor did it altered the activation and inactivation gating properties of cardiac Ca2+ channels. Meanwhile, SM decreased the amplitude of myocyte shortening and the peak value of Ca2+ transient with a significant decrease in the time to 90% of the baseline (Tr), but the time to 10% of the peak (Tp) was not dramatically prolonged. The results indicated that SM significantly inhibited L-type Ca2+ channels, decreased [Ca2+]i and contractility in adult rat cardiac myocytes. These findings may be relevant to the cardioprotective efficacy of SM." @default.
- W2085403911 created "2016-06-24" @default.
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- W2085403911 date "2014-12-01" @default.
- W2085403911 modified "2023-10-10" @default.
- W2085403911 title "Salvia miltiorrhiza (Danshen) inhibits L-type calcium current and attenuates calcium transient and contractility in rat ventricular myocytes" @default.
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- W2085403911 doi "https://doi.org/10.1016/j.jep.2014.10.049" @default.
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