FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085408461> ?p ?o ?g. }

• W2085408461 endingPage "446" @default.
• W2085408461 startingPage "442" @default.
• W2085408461 abstract "Rola, R., Otsuka, S., Obenaus, A., Nelson, G. A., Limoli, C. L., VandenBerg, S. R. and Fike, J. R. Indicators of Hippocampal Neurogenesis are Altered by 56Fe-Particle Irradiation in a Dose-Dependent Manner. Radiat. Res. 162, 442–446 (2004).The health risks to astronauts exposed to high-LET radiation include possible cognitive deficits. The pathogenesis of radiation-induced cognitive injury is unknown but may involve loss of neural precursor cells from the subgranular zone (SGZ) of the hippocampal dentate gyrus. To address this hypothesis, adult female C57BL/6 mice received whole-body irradiation with a 1 GeV/nucleon iron-particle beam in a single fraction of 0, 1, 2 and 3 Gy. Two months later mice were given BrdU injections to label proliferating cells. Subsequently, hippocampal tissue was assessed using immunohistochemistry for detection of proliferating cells and immature neurons. Routine histopathological methods were used to qualitatively assess tissue/cell morphology in the hippocampal formation and adjacent areas. When compared to controls, irradiated mice showed progressively fewer BrdU-positive cells as a function of dose. This observation was confirmed by Ki-67 immunostaining in the SGZ showing reductions in a dose-dependent fashion. The progeny of the proliferating SGZ cells, i.e. immature neurons, were visualized by doublecortin staining and were significantly reduced by irradiation, with the decreases ranging from 34% after 1 Gy to 71% after 3 Gy. Histopathology showed that in addition to cell changes in the SGZ, 56Fe particles induced a chronic and diffuse astrocytosis and changes in pyramidal neurons in and around the hippocampal formation. The present data provide the first evidence that high-LET radiation has deleterious effects on cells associated with hippocampal neurogenesis." @default.
• W2085408461 created "2016-06-24" @default.
• W2085408461 creator A5002484869 @default.
• W2085408461 creator A5020581447 @default.
• W2085408461 creator A5032967908 @default.
• W2085408461 creator A5039884124 @default.
• W2085408461 creator A5054373762 @default.
• W2085408461 creator A5083388815 @default.
• W2085408461 creator A5084243671 @default.
• W2085408461 date "2004-10-01" @default.
• W2085408461 modified "2023-10-10" @default.
• W2085408461 title "Indicators of Hippocampal Neurogenesis are Altered by⁵⁶Fe-Particle Irradiation in a Dose-Dependent Manner" @default.
• W2085408461 cites W1581458838 @default.
• W2085408461 cites W1590632482 @default.
• W2085408461 cites W1987002080 @default.
• W2085408461 cites W2021551531 @default.
• W2085408461 cites W2030060876 @default.
• W2085408461 cites W2042154782 @default.
• W2085408461 cites W2054538771 @default.
• W2085408461 cites W2064994363 @default.
• W2085408461 cites W2071181288 @default.
• W2085408461 cites W2098137179 @default.
• W2085408461 cites W2099250398 @default.
• W2085408461 cites W2103081123 @default.
• W2085408461 cites W2114976245 @default.
• W2085408461 cites W2117248906 @default.
• W2085408461 cites W2140129376 @default.
• W2085408461 cites W2141998956 @default.
• W2085408461 cites W2151497988 @default.
• W2085408461 cites W2237075569 @default.
• W2085408461 cites W2244201384 @default.
• W2085408461 doi "https://doi.org/10.1667/rr3234" @default.
• W2085408461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15447038" @default.
• W2085408461 hasPublicationYear "2004" @default.
• W2085408461 type Work @default.
• W2085408461 sameAs 2085408461 @default.
• W2085408461 citedByCount "83" @default.
• W2085408461 countsByYear W20854084612012 @default.
• W2085408461 countsByYear W20854084612013 @default.
• W2085408461 countsByYear W20854084612014 @default.
• W2085408461 countsByYear W20854084612015 @default.
• W2085408461 countsByYear W20854084612016 @default.
• W2085408461 countsByYear W20854084612017 @default.
• W2085408461 countsByYear W20854084612018 @default.
• W2085408461 countsByYear W20854084612019 @default.
• W2085408461 countsByYear W20854084612020 @default.
• W2085408461 countsByYear W20854084612021 @default.
• W2085408461 countsByYear W20854084612022 @default.
• W2085408461 countsByYear W20854084612023 @default.
• W2085408461 crossrefType "journal-article" @default.
• W2085408461 hasAuthorship W2085408461A5002484869 @default.
• W2085408461 hasAuthorship W2085408461A5020581447 @default.
• W2085408461 hasAuthorship W2085408461A5032967908 @default.
• W2085408461 hasAuthorship W2085408461A5039884124 @default.
• W2085408461 hasAuthorship W2085408461A5054373762 @default.
• W2085408461 hasAuthorship W2085408461A5083388815 @default.
• W2085408461 hasAuthorship W2085408461A5084243671 @default.
• W2085408461 hasConcept C134018914 @default.
• W2085408461 hasConcept C136834591 @default.
• W2085408461 hasConcept C142724271 @default.
• W2085408461 hasConcept C148762608 @default.
• W2085408461 hasConcept C169760540 @default.
• W2085408461 hasConcept C185592680 @default.
• W2085408461 hasConcept C204232928 @default.
• W2085408461 hasConcept C2776464000 @default.
• W2085408461 hasConcept C2777542384 @default.
• W2085408461 hasConcept C2781161787 @default.
• W2085408461 hasConcept C2781176699 @default.
• W2085408461 hasConcept C2781461022 @default.
• W2085408461 hasConcept C28328180 @default.
• W2085408461 hasConcept C2908656565 @default.
• W2085408461 hasConcept C4224716 @default.
• W2085408461 hasConcept C4746552 @default.
• W2085408461 hasConcept C48261664 @default.
• W2085408461 hasConcept C71924100 @default.
• W2085408461 hasConcept C86803240 @default.
• W2085408461 hasConcept C95444343 @default.
• W2085408461 hasConceptScore W2085408461C134018914 @default.
• W2085408461 hasConceptScore W2085408461C136834591 @default.
• W2085408461 hasConceptScore W2085408461C142724271 @default.
• W2085408461 hasConceptScore W2085408461C148762608 @default.
• W2085408461 hasConceptScore W2085408461C169760540 @default.
• W2085408461 hasConceptScore W2085408461C185592680 @default.
• W2085408461 hasConceptScore W2085408461C204232928 @default.
• W2085408461 hasConceptScore W2085408461C2776464000 @default.
• W2085408461 hasConceptScore W2085408461C2777542384 @default.
• W2085408461 hasConceptScore W2085408461C2781161787 @default.
• W2085408461 hasConceptScore W2085408461C2781176699 @default.
• W2085408461 hasConceptScore W2085408461C2781461022 @default.
• W2085408461 hasConceptScore W2085408461C28328180 @default.
• W2085408461 hasConceptScore W2085408461C2908656565 @default.
• W2085408461 hasConceptScore W2085408461C4224716 @default.
• W2085408461 hasConceptScore W2085408461C4746552 @default.
• W2085408461 hasConceptScore W2085408461C48261664 @default.
• W2085408461 hasConceptScore W2085408461C71924100 @default.
• W2085408461 hasConceptScore W2085408461C86803240 @default.
• W2085408461 hasConceptScore W2085408461C95444343 @default.
• W2085408461 hasIssue "4" @default.

• next