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- W2085408927 abstract "The liniment used is a topical analgesic and anti-inflammatory preparation containing two active constituents, 3-phenylpropylsalicylate and ethyl-5-methoxysalicylate, in solution in isobutyl decanoate. It is known that 3-phenylpropylsalicylate is metabolised to salicylic acid and salicyluric acid and ethyl-5-methoxysalicylate is metabolised to 5-methoxysalicylic acid and gentisic acid. In the present study the separation of the salicylates and their metabolites was carried out on a Waters μBondapak C18 column using two different mobile phases, methanol—water (80:20) for the parent drugs and methanol—5% aqueous acetic acid (27:73) for their metabolites. The salicylates and their metabolites were detected by absorption at 310 nm. The limits of detection for parent drugs and metabolites were respectively 0.2 and 0.1 μg/ml in plasma, using a 1-ml plasma sample and a 20-μl injection from a reconstituted volume of 250 μl. Mean percentage coefficients of variation for intra-assay and inter-assay precision were between 3.3 ± 1.9% to 9.1 ± 3.7% and 6.8 ± 2.2% to 15.7 ± 10.1%, respectively. Linearity, as measured by the correlation coefficient of intra-assay linear regression curves, was better than 0.998 in all cases." @default.
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- W2085408927 date "1985-01-01" @default.
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- W2085408927 title "High-performance liquid chromatographic determination of certain salicylates and their major metabolites in plasma following topical administration of a liniment to healthy subjects" @default.
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- W2085408927 doi "https://doi.org/10.1016/s0378-4347(00)84522-3" @default.
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