Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085428181> ?p ?o ?g. }
- W2085428181 endingPage "855" @default.
- W2085428181 startingPage "843" @default.
- W2085428181 abstract "Novel anticoagulants to replace unfractionated heparins, low molecular weight heparins and vitamin K antagonists, are needed urgently. Coagulation factor Xa is an attractive target for drug development because of its position at the convergence of the intrinsic and extrinsic clotting pathways. There are two differing strategies of inhibiting factor Xa that are being pursued: indirect inhibition by compounds such as fondaparinux and idraparinux, requiring antithrombin as a cofactor; and direct inhibition by compounds such as rivaroxaban (BAY 597939), DX-9065a, otamixaban, LY517717 and YM150. Of these compounds, fondaparinux is approved for the prevention and treatment of venous thromboembolism, and idraparinux is in Phase III for venous thromboembolism treatment and stroke prevention in patients with atrial fibrillation. Rivaroxaban has undergone extensive Phase II studies for venous thromboembolism prevention after orthopaedic surgery, and Phase III studies have begun. In this review, we will discuss the pharmacological effects of factor Xa inhibitors and the latest clinical developments." @default.
- W2085428181 created "2016-06-24" @default.
- W2085428181 creator A5009167101 @default.
- W2085428181 creator A5040870075 @default.
- W2085428181 date "2006-07-21" @default.
- W2085428181 modified "2023-10-09" @default.
- W2085428181 title "Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases" @default.
- W2085428181 cites W1557422402 @default.
- W2085428181 cites W1690312263 @default.
- W2085428181 cites W1804375307 @default.
- W2085428181 cites W1833703938 @default.
- W2085428181 cites W1860102466 @default.
- W2085428181 cites W1886476141 @default.
- W2085428181 cites W1970619525 @default.
- W2085428181 cites W2000130043 @default.
- W2085428181 cites W2007515753 @default.
- W2085428181 cites W2011085863 @default.
- W2085428181 cites W2012516190 @default.
- W2085428181 cites W2012761317 @default.
- W2085428181 cites W2018183727 @default.
- W2085428181 cites W2019561783 @default.
- W2085428181 cites W2021621876 @default.
- W2085428181 cites W2022932023 @default.
- W2085428181 cites W2023320697 @default.
- W2085428181 cites W2024334081 @default.
- W2085428181 cites W2024723340 @default.
- W2085428181 cites W2025768989 @default.
- W2085428181 cites W2028162842 @default.
- W2085428181 cites W2041726150 @default.
- W2085428181 cites W2042096176 @default.
- W2085428181 cites W2042190470 @default.
- W2085428181 cites W2045987573 @default.
- W2085428181 cites W2045998097 @default.
- W2085428181 cites W2047631866 @default.
- W2085428181 cites W2053677326 @default.
- W2085428181 cites W2054169479 @default.
- W2085428181 cites W2057065644 @default.
- W2085428181 cites W2060231998 @default.
- W2085428181 cites W2064826963 @default.
- W2085428181 cites W2066676409 @default.
- W2085428181 cites W2075341962 @default.
- W2085428181 cites W2076391495 @default.
- W2085428181 cites W2077207459 @default.
- W2085428181 cites W2078415463 @default.
- W2085428181 cites W2080318130 @default.
- W2085428181 cites W2081561904 @default.
- W2085428181 cites W2082739034 @default.
- W2085428181 cites W2085548132 @default.
- W2085428181 cites W2088494721 @default.
- W2085428181 cites W2089995463 @default.
- W2085428181 cites W2091825028 @default.
- W2085428181 cites W2095901832 @default.
- W2085428181 cites W2096435224 @default.
- W2085428181 cites W2098108939 @default.
- W2085428181 cites W2099094229 @default.
- W2085428181 cites W2122285449 @default.
- W2085428181 cites W2133155409 @default.
- W2085428181 cites W2134355273 @default.
- W2085428181 cites W2134908914 @default.
- W2085428181 cites W2151668293 @default.
- W2085428181 cites W2153196285 @default.
- W2085428181 cites W2160840488 @default.
- W2085428181 cites W2166945512 @default.
- W2085428181 cites W2170550513 @default.
- W2085428181 cites W2229852001 @default.
- W2085428181 cites W2325632732 @default.
- W2085428181 cites W2408801358 @default.
- W2085428181 cites W2560491673 @default.
- W2085428181 cites W2561317409 @default.
- W2085428181 cites W2590769968 @default.
- W2085428181 cites W303444848 @default.
- W2085428181 cites W4206125459 @default.
- W2085428181 cites W4253259085 @default.
- W2085428181 cites W45169395 @default.
- W2085428181 cites W70145905 @default.
- W2085428181 doi "https://doi.org/10.1517/13543784.15.8.843" @default.
- W2085428181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16859389" @default.
- W2085428181 hasPublicationYear "2006" @default.
- W2085428181 type Work @default.
- W2085428181 sameAs 2085428181 @default.
- W2085428181 citedByCount "98" @default.
- W2085428181 countsByYear W20854281812012 @default.
- W2085428181 countsByYear W20854281812013 @default.
- W2085428181 countsByYear W20854281812014 @default.
- W2085428181 countsByYear W20854281812015 @default.
- W2085428181 countsByYear W20854281812016 @default.
- W2085428181 countsByYear W20854281812017 @default.
- W2085428181 countsByYear W20854281812018 @default.
- W2085428181 countsByYear W20854281812019 @default.
- W2085428181 countsByYear W20854281812020 @default.
- W2085428181 countsByYear W20854281812021 @default.
- W2085428181 countsByYear W20854281812023 @default.
- W2085428181 crossrefType "journal-article" @default.
- W2085428181 hasAuthorship W2085428181A5009167101 @default.
- W2085428181 hasAuthorship W2085428181A5040870075 @default.
- W2085428181 hasConcept C126322002 @default.
- W2085428181 hasConcept C2776301958 @default.
- W2085428181 hasConcept C2776877702 @default.