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• W2085431744 abstract "Water sensation is a specific taste modality in the fruit fly. Water-induced hypoosmolarity activates specific gustatory receptor neurons; however, the molecular identity of the putative osmolarity sensor in these neurons remains unknown. We found that amiloride and its analogs specifically antagonized the response of water gustatory receptor neurons and the behavior of flies toward water stimulation. Deletion of the gene that encodes the amiloride-sensitive PPK28 channel, a DEG/eNaC (degenerin/epithelial sodium channel) family member, abolished the water-induced activity of water gustatory receptor neurons and greatly diminished the behavioral response of flies to water. Ectopic expression of the PPK28 channel in the bitter cells within the intermediate-type sensilla renders these sensilla responsive to water stimuli. Thus, the amiloride-sensitive PPK28 channel may serve as the osmolarity sensor for gustatory water reception in the fruit fly." @default.
• W2085431744 created "2016-06-24" @default.
• W2085431744 creator A5028860196 @default.
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• W2085431744 date "2010-05-05" @default.
• W2085431744 modified "2023-09-24" @default.
• W2085431744 title "The Amiloride-Sensitive Epithelial Na⁺Channel PPK28 Is Essential for<i>Drosophila</i>Gustatory Water Reception" @default.
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• W2085431744 doi "https://doi.org/10.1523/jneurosci.0627-10.2010" @default.
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