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W2085432582 abstract "Introduction Rush immunotherapy is a method for rapidly desensitizing patients to inhalant allergens. The frequency of systemic reactions during rush immunotherapy is similar to conventional immunotherapy when premedication is used. The most rapid protocol for rush immunotherapy reported to date requires one and one-half days which is inconvenient to patients and clinic schedules. To improve this situation and decrease the cost of giving rush immunotherapy, we have developed a 1-day protocol. Methods For this ongoing study, 22 allergic patients received rush immunotherapy consisting of 8 injections over 6 hours followed by 2 hours of observation in an outpatient clinic. Five had rhinitis and the rest asthma, 7 of whom were steroid-dependent. All were premedicated with astemizole, ranitidine, and prednisone for 3 days including the day of rush immunotherapy, and peak expiratory flow rates were monitored. Results Systemic reactions were seen in 5 of 22 (23%). They occurred following the sixth injection (1), seventh injection (2), or the final one (2) and consisted primarily of rhinitis or pulmonary symptoms with one episode of mild anaphylaxis. A systemic reaction was seen in only 1 steroid-dependent asthmatic patient. A local reaction preceded a systemic reaction in only 1 patient. All but 3 reached a maintenance dose in 1 day. All systemic reactions responded to epinephrine and all patients could go home after rush immunotherapy. Only one patient had a systemic reaction during the 3 months after rush immunotherapy. Conclusions One-day rush immunotherapy is tolerated by most patients with a systemic reaction rate comparable to conventional immunotherapy. All patients were able to reach a maintenance dose months sooner than with weekly schedules. With refinement of this procedure, rush immunotherapy may become a widely used method for desensitizing patients with inhalant allergens, and could make immunotherapyless expensive and more convenient." @default.
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W2085432582 modified "2023-10-16" @default.
W2085432582 title "Rush Immunotherapy: Experience with a One-Day Schedule" @default.
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W2085432582 doi "https://doi.org/10.1016/s1081-1206(10)63419-9" @default.
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